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Skip to Search Results- 6Myocardial infarction
- 1 Coronary artery disease
- 1Calpain
- 1Cardiac output
- 1Cardiac troponin
- 1Cardiography
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Fall 2018
Background: Type 2 myocardial infarction (T2MI), or myocardial necrosis due to supply-demand mismatch, poses significant diagnostic and management challenges for clinicians. We conducted a detailed clinical characterization of management and outcomes of a large population of T2MI patients,...
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Structure and proteolytic digestion of the intrinsically disordered C-terminal tail of cardiac troponin I
DownloadSpring 2019
Intrinsically disordered regions (IDRs) are protein sequences that do not acquire a fixed 3-D configuration under physiologic conditions. Their solvent-exposed nature makes them susceptible to post-translational modifications like proteolysis, which makes them vital for cellular regulation....
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Structure and proteolytic susceptibility of the inhibitory C-terminal tail of cardiac troponin I
Download2019-01-01
Mahmud, Zabed, Zahran, Somaya, Liu, Philip B., Reiz, Bela, Chan, Brandon Y.H., Roczkowsky, Andrej, McCartney, Christian-Scott E., Davies, Peter L., Li, Liang, Schulz, Richard, Hwang, Peter M.
Background Cardiac troponin I (cTnI) has two flexible tails that control the cardiac cycle. The C-terminal tail, cTnI135-209, binds actin to shut off cardiac muscle contraction, whereas the competing calcium-dependent binding of the switch region, cTnI146-158, by cardiac troponin C (cTnC)...
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The prognosis and outcomes of patients with a ST-segment elevation myocardial infarction and the biochemical and clinical inflammatory response
DownloadSpring 2013
Acute myocardial infarction, and specifically coronary plaque rupture, has been associated with a systemic inflammatory cascade. Using multiple large clinical trial datasets, we sought to further understand the systemic and clinical inflammatory responses in patients with ST-elevation myocardial...