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- 1Deng, Xiaodan
- 1Deslauriers, Andre
- 1Elkady, Ahmed
- 1Frieser, Emma CG
- 1Jonzon, Alison Jill
- 1Marino, Angela
Amino acid and biogenic amine concentrations during experimental autoimmune encephalomyelitis and the disease-modifying effects of phenelzine treatmentDownload
The project described in this thesis began with a broad analysis of the changes to amino acid and biogenic amine concentrations in the central nervous system (CNS) during experimental autoimmune encephalomyelitis (EAE) in mice, an animal model of Multiple Sclerosis (MS). That study identified...
This study described the play experiences of daughters who were caregivers to their mothers with multiple sclerosis (MS). The experiences of four Canadian-Caucasian women aged 19-26 were captured using phenomenological methods of individual and focus group interviews, field notes, and artefacts....
Development and Application of Quantitative Gradient-Echo MRI Techniques for Assessment of Iron and Myelin in the Multiple Sclerosis BrainDownload
Multiple Sclerosis (MS) is a progressive autoimmune and neurodegenerative disease of the Central Nervous System that results in demyelination and neuronal/axonal loss. Along with clinical evaluation, Magnetic Resonance Imaging (MRI) is the gold standard modality for diagnosing and monitoring MS,...
Magnetic resonance imaging (MRI) is a valuable imaging modality and is commonplace in diagnosing, evaluating, and understanding the pathobiology of many neurological disorders. Current methods are helpful in the diagnosis of multiple sclerosis (MS) but fail to provide useful longitudinal...
Endoplasmic reticulum stress induction by an endogenous retrovirus glycoprotein during neuroinflammation: regulation by a free radical scavengerDownload
Endoplasmic reticulum (ER) stress is a homeostatic mechanism, which is utilized by cells to adapt to inter- and intra-cellular changes. There is a burgeoning literature showing that the human endogenous retroviral envelope glycoprotein, Syncyin-1, oxidative stress and reactive oxygen species...
Diagnosed in 2009 with Multiple Sclerosis, my mother’s mental and physical health deteriorated at a rapid pace. The person who raised me was altered, becoming someone who was less confident in her abilities and saw her disease as a defeat. I grew to resent this new person, seeing her as the...
Functional data analysis (FDA) is a fast-growing area in statistics with the aim of estimating a set of related functions or curves rather than focusing on a single entity, like estimating a point, as in classical statistics. FDA has a wide range of applications in different fields such as...
Investigating the Effects of N2-Acetylphenelzine in the Sexes in Experimental Autoimmune EncephalomyelitisDownload
Chronic pain is a highly prevalent symptom in Multiple Sclerosis (MS) and affects approximately half of patients at some stage of the disease. MS affects women more frequently than men and neuropathic pain is also reported as more severe, and frequent, in females with the disease. The underlying...
Quantitative transverse relaxometry is an MRI method that has shown promise for study of iron accumulation and demyelination in healthy brain and in associated neurological disorders. Multiple sclerosis (MS) is one such neurodegenerative disorder in which iron accumulation in deep grey matter...
The Role of Mitochondrial Dynamics on Neurodegenerative Processes of Multiple Sclerosis in Respose to Inflammation and Endoplasmic Reticulum StressDownload
Biopsies and post-mortem tissue of patients with multiple sclerosis (MS) as well as inflammatory demyelinating animal models show that endoplasmic reticulum (ER) stress is a hallmark of the progression of these pathologies. Moreover, MS biopsies and animal models of neuroinflammatory diseases...