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Skip to Search Results- 3DNA damage
- 3Molecular beacons
- 12-aminopurine
- 1Chimeric RNA DNA probe
- 1Excited-state structural dynamics
- 1Fluorescence
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Spring 2012
In this thesis, we develop a sensitive, robust, accurate method to detect chemically-induced DNA damage by three therapeutic agents, cisplatin, psoralen and busulfan. The method uses fluorescence spectroscopy and fluorescent hairpin or molecular beacon probes in a hybridization assay for...
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Spring 2013
Absorption of UV light by nucleic acids can result in the formation of molecular lesions leading to mutagenesis, carcinogenesis, and cell death. Thus, understanding DNA damage is important for elucidating the molecular mechanisms of disease. Much effort has been focused on developing methods for...
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Novel spectroscopic probes of sunscreens, initial excited-state structural dynamics and DNA photodamage
DownloadSpring 2010
This thesis discusses developing new tools to probe DNA damage resulting from photoinduced chemical processes and probing the initial excited-state structural dynamics of nucleic acids and sunscreen agents. The results of this thesis show that UV resonance Raman spectroscopy (UVRRS) is an...