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Skip to Search Results- 1Akhnokh, Maria Kodsy
- 1BATCHU, SRI NAGARJUN
- 1Bai, Helin Daniel
- 1Bosnjak, Natasa
- 1Close, Anne-Françoise J
- 1Dromparis, Peter R
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Fall 2013
Glomus cells of the carotid body are peripheral chemoreceptors that detect changes in arterial oxygen levels. Hypoxia suppresses oxygen-sensitive K+ channels in glomus cells, resulting in cytosolic Ca2+ ([Ca2+]i) elevation in glomus cells via the activation of voltage-gated Ca2+ channels. The...
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Regulation of Pancreatic β-cell Life and Death in the Context of Type 2 Diabetes: Study of the Potential Implication of the Orphan Nuclear Receptor NR4A3/Nor1 and the NZF Transcription Factor ST18.
DownloadFall 2017
Background: The insulin-secreting pancreatic beta-cell plays a central role in the maintenance of glucose homeostasis and in the pathogenesis of both type 1 and type 2 diabetes mellitus. In both cases, production of pro-inflammatory cytokines causes beta-cell apoptosis, which results in the...
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Fall 2009
This project investigated the effects of exercise and epinephrine on the mRNA expression of peroxisome proliferator activated receptor gamma coactivator-1 alpha (PGC-1 alpha), a master regulator of mitochondrial biogenesis, in rat adipose tissue. Rats that swam 2 hours daily for 4 weeks had...
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Spring 2016
Mitochondria are at the center of cardiac health and disease. These vital organelles provide most of the energy to the contractile apparatus and play a strategic role in cardiomyocyte survival during cellular stress. Cardiovascular diseases and many aging related diseases are often associated...
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Fall 2023
12,13-dihydroxy-9z-octadecenoic acid (12,13-DiHOME) is a linoleic acid-derived cardiac metabolite produced in endotoxin-induced cardiomyopathy, correlating with myocardial dysfunction, inflammation, and mitochondrial damage. The contribution of 12,13-DiHOME to inflammation in the heart is...
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Fall 2019
Breast cancer is the leading cause of death among women worldwide. Fortunately, death rates have been declining since 1990, due to the increase in early detection, testing, and improved treatment. However, despite the advancement of targeted and hormone therapies for certain molecular sub-types...
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The Cardioprotective Role of the N-3 PUFA Metabolite 19,20-Epoxydocosapentaenoic Acid (19,20-EDP) in the Setting of Ischemia Reperfusion Injury
DownloadSpring 2022
Ischemic heart disease (IHD) is a leading cause of cardiovascular morbidity and mortality worldwide. Myocardial ischemia occurs when a coronary artery is occluded and consequently blood supply to the heart is restricted depleting it of oxygen and nutrients. Although early myocardial reperfusion,...
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The metabolic basis of cell identity in the pulmonary arteries and the right ventricle in pulmonary arterial hypertension
DownloadFall 2023
Pulmonary arterial hypertension (PAH) is an incurable disease characterized by profound pulmonary vascular remodeling, including the development of plexogenic lesions (which is the hallmark of PAH) that results in lumen obliteration, raising the pulmonary vascular resistance (PVR) and the right...