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- 3Neupert, W.
- 2Nargang, F. E.
- 1Ahting, U.
- 1Akhnokh, Maria Kodsy
- 1BATCHU, SRI NAGARJUN
- 1Bahitham, Wesam
- 25Graduate Studies and Research, Faculty of
- 25Graduate Studies and Research, Faculty of/Theses and Dissertations
- 3Biological Sciences, Department of
- 3Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 2Agricultural, Food and Nutritional Science, Department of
- 2Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
The TOB (Topogenesis of Outer membrane β-barrel proteins) complex is composed of the core proteins Tob55 (Sam50), Tob37 (Sam37) and Tob38 (Sam35). The complex facilitates the insertion of all β-barrel and some α-helically anchored integral proteins into the mitochondrial outer membrane (MOM)....
Biogenesis of Porin of the Outer Mitochondrial Membrane Involves an Import Pathway via Receptors and the General Import Pore of the TOM ComplexDownload
Abstract: Porin, also termed the voltage-dependent anion channel, is the most abundant protein of the mitochondrial outer membrane. The process of import and assembly of the protein is known to be dependent on the surface receptor Tom20, but the requirement for other mitochondrial proteins...
Primary Biliary Cholangitis (PBC) is a chronic liver disease characterized by the immune-mediated destruction of intra-hepatic bile ducts. The autoimmune nature of PBC involves humoral and cell-mediated responses that target endogenous mitochondrial proteins. It is thought that the breakdown of...
The analysis of wide-angle cellular light scattering patterns is a challenging problem. Small changes to the organization, orientation, shape, and optical properties of scatterers and scattering populations can significantly alter their complex two-dimensional scattering signatures. Because of...
The pathological events initiating diabetic cardiac changes in response to chronic hyperglycemia and hyperinsulinemia remain unclear. Due to the high metabolic activity of the heart, and its sensitivity to acute changes in oxygen and substrate flux, mitochondrial dysfunction has been proposed as...
Multiple sources suggest that insulin resistance and derangements of cardiac metabolism are among the earliest signs of type-2 diabetes detected in the heart. Unfortunately, limited evidence reflects early changes in cardiac mitochondrial metabolism linked to the development of this disease....
Deregulated TNF signaling with elevated or decreased levels of TNF-induced apoptosis causes numerous inflammatory and cancerous diseases. Thus, there is a clear need to identify cellular proteins that regulate cell fate in the presence of TNF. RNA interference technology provides an excellent...
Background Adipose tissue mitochondria have been implicated as key mediators of systemic metabolism. We have shown that IL-6 activates AMPK, a mediator of mitochondrial biogenesis, in adipose tissue; however, IL-6−/− mice fed a high fat diet have been reported to develop insulin resistance. These...
Mitochondrial dysfunction is considered as a key mechanism of aging but little is known about the impact of mitochondrial biogenesis. Mitochondrial DNA (mtDNA) copy number control is an important aspect of mitochondrial biogenesis and is highly regulated in eukaryotic organisms. By studying mtDNA...
Investigation of transcriptional and translational regulation of the Neurospora crassa alternative oxidaseDownload
Mitochondria are organelles found in most eukaryotes and supply the cell with the majority of its energy needs in the form of ATP. Most of the proteins needed for mitochondrial function are nuclear encoded. Therefore, mitochondria communicate their functional status to the nucleus, resulting in...