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Bioinformatic analyses in early host response to Porcine Reproductive and Respiratory Syndrome virus PRRSV reveals pathway differences between pigs with alternate genotypes for a major host response QTL
Download2016-03-08
Bao, Hua, Schroyen, Martine, Rowland, Robert R.R., Guan, Le L., Stothard, Paul, Reecy, James M., Fritz-Waters, Eric, Koltes, James E., Kommadath, Arun, Plastow, Graham S., Eisley, Christopher, Tuggle, Christopher K. , Dekkers, Jack C.M., Lunney, Joan K., Choi, Igseo
Background A region on Sus scrofa chromosome 4 (SSC4) surrounding single nucleotide polymorphism (SNP) marker WUR10000125 (WUR) has been reported to be strongly associated with both weight gain and serum viremia in pigs after infection with PRRS virus (PRRSV). A proposed causal mutation in the...
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Characterisation of genetic variation in the pig breeds of China and Europe – The PigBioDiv2 project.
Download2003
Haley, C., Li, K., Plastow, G. , Cardellino, R., Andersson, L., SanCristobal, M., Li, N., Huang, L., Chevalet, C., Blott, S., Groenen, M.
The PigBioDiv2 project will evaluate and compare genetic diversity among the pig breeds of China and Europe. At least 50 Chinese breeds will be sampled and compared with 59 European breeds previously sampled in the PigBioDiv1 project. The European pig biodiversity database will be extended to at...
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2001
Ciobanu, D. C., Nagy, A., Day, A. E., Plastow, G. S., Rothschild, M. F., Wales, R.
Analysis of the genetic variation of an endangered population is an important component for the success of conservation. Animals from two local Romanian pig breeds, the Mangalitsa and Bazna, were analysed for variation at a number of genetic loci using PCR-based DNA tests. Polymorphism was...
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Genome-wide association studies (GWAS) identify a QTL close to PRKAG3 affecting meat pH and colour in crossbred commercial pigs
Download2015
Miar, Y., Plastow, G. S., Charagu, P., Wang, Z., Kemp, R. A., Bruce, H., Zhang, Z., Yang, T.
Background Improving meat quality is a high priority for the pork industry to satisfy consumers’ preferences. GWAS have become a state-of-the-art approach to genetically improve economically important traits. However, GWAS focused on pork quality are still relatively rare. Results Six...
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Increasing gene discovery and coverage using RNA-seq of globin RNA reduced porcine blood samples
Download2014
Stothard, P., Fritz-Waters, E., Choi, I., Abrams, S. M., Kommadath, A., Hosseini, A., Plastow, G. S., Guan, L. L., Tuggle, C. K., Bao, H., Meng, Y., Lunney, J. K., Reecy, J. M., Sun, X.
Background Transcriptome analysis of porcine whole blood has several applications, which include deciphering genetic mechanisms for host responses to viral infection and vaccination. The abundance of alpha- and beta-globin transcripts in blood, however, impedes the ability to cost-effectively...
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2003
Mitsuhashi, T., Andersson, L. , Carrion, D., Haley, C., Archibald, A., Evans, G., Plastow, G., Day, A.
We describe the characterisation of the two main coat colour determining loci (MC1R and KIT) for pigs and demonstrate how this information can be utilized for breed identification. These approaches can be useful components of quality assurance and traceability schemes which are increasingly...
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2003
Heuven, H. , Plastow, G., Peleman, J., Siggens, K., Brugmanns, B., Bagga, M.
AFLP® was utilized successfully as a tool to generate a large number (more than 100) of DNA markers in a total of 2435 individuals from the EC Pig Biodiversity project. This information was used for an initial genetic distance analysis with the results tending to group the lines and breeds as...