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Skip to Search Results- 2Matrix metalloproteinases
- 1Aortic aneurysm
- 1Extracellular matrix
- 1Neonatal cardiomyocytes and cardiofibroblasts isolation
- 1Pressure overload cardiac disease
- 1Reactive nitrogen species
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Spring 2014
With matrix metalloproteinases-2 (MMP2) deficiency, we observed thoracic aortic aneurysm in 70% of MMP2-/- mice but no abdominal aortic aneurysm following four weeks of angiotensin II (Ang II) infusion. We found markedly suppressed recoil properties in the thoracic aorta of MMP2-/-- Ang II mice....
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Tumor necrosis factor triggers the expression and activation of matrix metalloproteinases through NADPH-dependent superoxide production
DownloadSpring 2010
Tumor necrosis factor (TNF) is upregulated in a number of cardiomyopathies. This thesis investigates TNF in triggering the expression and activation of matrix metalloproteinases (MMPs) in pressure overload cardiac disease, and explores the role of superoxide. Cardiac pressure overload was...