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Skip to Search Results- 2Lovastatin
- 1Acyl carrier protein
- 1Biological Diels-Alder reaction
- 1Biosynthesis
- 1Chaetoglobosin
- 1Cladosporin
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Biochemical investigations of two polyketide synthase subclasses – highly reducing/non-reducing pairs, and polyketide synthase non-ribosomal peptide synthetases.
DownloadSpring 2016
Cladosporin is a polyketide metabolite that is biosynthesized by a highly reducing (HR)/non-reducing (NR) polyketide synthase (PKS) pair, wherein they catalyse head-totail condensation of acetyl and malonyl CoA units with subsequent β-keto modification. Cladosporin has recently been reported as a...
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Investigations of Fungal Highly Reducing Polyketide Synthases: The Biosyntheses of Lovastatin and Hypothemycin
DownloadFall 2017
Fungal highly reducing polyketide synthases (HR-PKSs) are large, multi-domain enzymes central to the biosynthesis of fungal polyketides. They assemble complex secondary metabolites, called polyketides, through the condensation of two-carbon acetate units and tailoring of the functional groups at...