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- 1Biological Sciences, Department of/Journal Articles (Biological Sciences)
Computational identification of residues that modulate voltage sensitivity of voltage-gated potassium channelsDownload
Background: Studies of the structure-function relationship in proteins for which no 3D structure is available are often based on inspection of multiple sequence alignments. Many functionally important residues of proteins can be identified because they are conserved during evolution. However,...
Fittings of simulated and live ion channel recordings
Results of bulk fittings of 5 simulated and 4 live ion channel recordings performed in QUB Express with the multiple optimization plugin.
We develop an approach for optimizing Hidden Markov model representations of voltage-gated ion channels that addresses the issues of topology determination and poorly performing optimization algorithms. Developing accurate models of neurological processes is a major goal of computational...
QUB Express Multiple Optimization Plugin
This plugin is designed to integrated into QUB-Express and enable data configuration and bulk optimization. Also included is a patch that allows QUB-Express to record state occupancy data and a set of scripts to calculate max deviation and generate LaTeX formatted tables that guide the...
The effect of long-term interleukin-1 beta exposure on sensory neuron electrical membrane properties: implications for neuropathic painDownload
The effect of interleukin-1 beta (IL-1β) on the electrical properties of sensory neurons was assessed at comparable levels and exposure times to those found in animal models of neuropathic pain. Experiments involved whole cell current- or voltage-clamp recordings from rat dorsal root ganglion...