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Bilateral Uterine Artery Ligation in Rats cultivates Long Term Neurological Deficits reminiscent of Human Cerebral Palsy: A model for Therapeutic Intervention.
DownloadFall 2015
Introduction Cerebral Palsy (CP) is a ubiquitous term used to describe a group of permanent, non-progressive disorders of movement, posture, and behaviour. Despite countless advances in neonatal medicine, the incidence of CP has remained constant in term infants over the last three decades. More...
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Spring 2014
Chronic trauma in childhood can program an abnormal stress reaction, resulting in lifelong difficulties with stress management and poor health outcomes linked to changes in the immune system. At the same time, maternal stress during pregnancy has been linked to childhood asthma. Given the...
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Maternal Overweight Prior to Pregnancy and its Impact on the Infant Gut Microbiome and Subsequent Child Overweight Risk
DownloadSpring 2015
Background: Maternal overweight and obesity is a widespread problem in Canada that has been linked to many complications during pregnancy. The gut microbiome has been revealed to have origins during infancy, which might be influenced by maternal weight gain during pregnancy. It would be...
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Pre and postnatal maternal distress and infant gut immunity in the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort
DownloadSpring 2017
Introduction: Secretory immunoglobulin A (sIgA) plays a critical role in gut mucosal immunity and is a marker of immune maturation in early life. Delayed IgA production is associated with increased risk of allergic diseases. Animal models of stressful events before birth and during infancy show...