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- 10Innate immunity
- 2Immunoregulatory receptors
Biochemical and Functional Characterization of Inhibitory Leukocyte Immune-Type Receptors in the Channel Catfish (Ictalurus punctatus)
Biochemical and Functional Characterization of Inhibitory Leukocyte Immune-Type Receptors in the Channel Catfish (Ictalurus punctatus)Download
A balance of intracellular signaling events control immune cell functions. In innate immunity, many of these signals are transmitted by subsets of cell surface proteins known as immunoregulatory receptors. Through their recognition of a diverse array of molecules these receptors effectively...
The fine balance struck between life and death is key for the health of all multicellular organisms and therefore the pathways that govern life and death decisions are evolutionarily highly conserved. For example, the human TNF and the Drosophila IMD pathways coordinate signaling elements such...
Commercial naphthenic acids and the organic fraction of oil sands process water downregulate pro-inflammatory gene expression and macrophage antimicrobial responses
Commercial naphthenic acids and the organic fraction of oil sands process water induce different effects on pro-inflammatory gene expression and macrophage phagocytosis in mice
In response to pathogens, immune cells induce protective effector functions, such as degranulation, phagocytosis and cytokine secretion, which are initiated by stimulatory or inhibitory immunoregulatory receptors expressed on leukocytes. Using a fish immunological model system, the focus of my...
Bovine Spongiform Encephalopathy (BSE) belongs to a group of neurodegenerative diseases known as transmissible spongiform encephalopathies (TSEs) which affect many species. From 1986 more than 184,000 cattle in the UK have been confirmed to be infected with this disease, and in Canada total...
Nutritional strategies to mitigate the loss of broiler performance due to the elimination of prophylactic antibiotics were investigated, consisting of two nutrient density starter diets (HIGH: 3,025 kcal/kg and 23.9% CP; LOW: 2,858 kcal/kg and 22.3% CP), 25-OH-D3 (0 or 69 µg/kg), and bacitracin...
The innate immune system is an evolutionarily conserved first line of defense against invasive microbes. Studies in the fruit fly, Drosophila melanogaster, revolutionized the field of immunology and cemented Drosophila as a premier model of innate immune defenses. The Drosophila immune deficiency...
The effect of maternal antioxidant nutrient supplementation and age on chick post-hatch innate immune functionDownload
The chick’s innate immune system may affect post-hatch liveability and performance, but is immature at hatch. The development of the immune system begins in ovo and may be affected by hen age and nutrition. Antioxidants are molecules capable of preventing and correcting oxidative damage and may...
The effects of broiler breeder diet supplementation of canthaxanthin and 25-hydroxyvitamin D3 and age on offspring performance traits and innate immune functionDownload
Experiments were conducted to understand the effect of dietary canthaxanthin (CXN) and 25-hydroxyvitamin D3 (25-OHD3) on broiler breeder productivity, progeny performance traits and progeny innate immune function. Beginning at 22 wk of age, breeder hens were fed either 1) Control (Vitamin D3 at...