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Characterization of Aerosol Deposition in Children and Infants Using Idealized Extrathoracic GeometriesDownload
This thesis describes a number of experimental studies performed with the common goal of characterizing pharmaceutical aerosol deposition in children and infants using idealized extrathoracic geometries. First, an in vitro study of the recently proposed Alberta Idealized Child Throat showed that...
Experimental evaluation and model development for analysis of pressure drop in the lungs of childrenDownload
Airway resistance describes the ratio between pressure drop and flow rate through the conducting respiratory airways. Analytical models of airway resistance for tracheobronchial airways have previously been developed and assessed without upper airways positioned upstream of the trachea. This...
Measurements of Total Aerosol Deposition and Validation of Airway Resistance Models in Anatomically Realistic Intrathoracic Conducting Airway Replicas of ChildrenDownload
One objective of this research was to obtain a correlation that quantitatively predicts micrometer-sized aerosol particle deposition in the upper conducting airways (trachea to generation 3) of children. Experiments were conducted using steady inhalation air flow rates to measure the deposition...