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Skip to Search Results- 1Akinwumi, Segun M
- 1Al-Rikabi, Hussain Isam
- 1Bhavanam,Sudha
- 1Crichton,Paul
- 1Dunsmore, Garett John
- 1Engelking, Lauren E.
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Characterization of Binding of LILRA3 and LILRB2 to the Myelin-Associated Inhibitors and Major Histocompatibility Class I Molecules
DownloadFall 2018
The leukocyte immunoglobulin-like receptor family (LILR) is composed of inhibitory and activating receptors that are widely expressed on immune cells and interact with classical and non-classical MHC-I. Recently, several ligands have been identified for the LILRs including the three...
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Fall 2024
The stochastic diversification of the T cell receptor (TCR) carries with it both the potential for recognizing virtually infinite foreign peptides, but also the potential for the erroneous recognition of self-peptides, which represents a threat of autoimmunity. During development in the thymus, T...
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Spring 2013
The adaptive immune response against intracellular pathogens is largely mediated by CD8+ T lymphocytes. The clonal expansion and expression of cytolytic and immune stimulatory proteins by CD8+ T cells is responsible for their protective immune function. Prior to exhibiting effector activity,...
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Creation of an in-vitro¬ Co-culture Model of Microglia and Retinal Pigment Epithelium Cells for Investigating the Innate Immune Mechanisms of the Retina
DownloadFall 2022
Background: The immune mechanisms of the retina in response to gene therapy have been previously understudied due to assumptions of ocular immune privilege. Ocular immune privilege is the concept that there is a tolerance or reduced immune response to antigen exposure in the eye. With the recent...
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Developing clinically translatable chimerism induction protocols in a stringent murine model
DownloadSpring 2020
Allogeneic hematopoietic chimerism induction via bone marrow transplantation (BMT) is thus far the most robust method for inducing donor antigen specific tolerance to allogeneic grafts. However, limited by the toxicity of the reagents used in conditioning the recipients, the demand of a high dose...
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Fall 2022
Affinity maturation is the process to improve antibody affinity for an antigen during an adaptive immune response; it is mediated by the immunoglobulin mutator enzyme activation-induced cytidine deaminase (AID). This process is crucial to produce high-affinity memory B-cells and plasma cells. In...
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Examining the Effects of Cytoplasmic Tail Splicing Event in Goldfish (Carassius auratus) Leukocyte Immune-type receptors
DownloadSpring 2024
The innate immune system is important in clearing infections and maintaining homeostasis. Across vertebrates, innate immunity is capable of executing potent effector responses through the actions of highly specialized cells. Effector responses, such as phagocytosis and cytokine secretion, are...
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Fall 2022
Background: Although pediatric heart transplantation is a life-saving and effective therapy for children with cardiac disease, barriers remain due to a lack of available organs as well as transplant failure due to rejection. This dissertation aimed to increase knowledge related to immune risk...
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Fall 2018
Tuberculosis (TB) is a chronic pulmonary disease caused by Mycobacterium tuberculosis (Mtb). Mtb spreads by aerosol and infects through the airways. Mtb is phagocytosed by macrophages in the lung, and is able to replicate inside these cells. The initial infection of Mtb with macrophage results in...
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Fall 2023
The calving transition is a challenging period for dairy cows characterized by negative energy balance, metabolic dysfunction, and inflammation, each of which may compromise milk production. Despite extensive research in this area, much is still unknown on how to best manage this period. The...