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Skip to Search Results- 13Platelets
- 11Immune responses
- 7Hematology
- 7Peripheral Blood Smear
- 6Platelet Abnormality
- 6Platelet Satellitism
- 7Villatoro, Valentin (Supervisor)
- 5Kwon, Gloria
- 5To, Michelle
- 2Ametaj, Burim N.
- 2Bao, Hua
- 2Dunn, Suzanna M.
- 9Medicine and Dentistry, Faculty of
- 7Graduate and Postdoctoral Studies (GPS), Faculty of
- 7Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 7Medicine and Dentistry, Faculty of/Medical Laboratory Science, Division of
- 4Agricultural, Food and Nutritional Science, Department of
- 4Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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Angiostatin inhibits endothelial MMP-2 and MMP-14 expression: A hypoxia specific mechanism of action
Download2013
Zielnik-Drabik, B., Jurasz, P., Radziwon-Balicka, A., Moncada de la Rosa, C., Ramer, C.
Angiostatin is an angiogenesis inhibitor in part generated by and released from platelets. Since platelets upon thrombus formation can give rise to areas of hypoxia, we investigated the effects of angiostatin on endothelial cell migration and apoptosis during hypoxia. Human microvascular...
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Differences in whole blood gene expression associated with infection time-course and extent of fetal mortality in a reproductive model of type 2 porcine reproductive and respiratory syndrome virus (PRRSV) infection
Download2016
Ladinig, Andrea, Stothard, Paul, Wilkinson, Jamie M., Kommadath, Arun, Plastow, Graham S., Harding, John C. S., Bao, Hua, Lunney, Joan K.
Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant females causes fetal death and increased piglet mortality, but there is substantial variation in the extent of reproductive pathology between individual dams. This study used RNA-sequencing to characterize the whole...
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Genesis and Characterization of Human eNOS-Based Platelet Subpopulations. Implications for Haemostasis and Thrombosis
DownloadFall 2019
Background: Myocardial infarction (MI) and ischemic stroke are responsible for nearly half of all cardiovascular deaths in Canada. Platelets play a critical role in MI and ischemic stroke by forming thrombi that occlude coronary and cerebral arteries. In spite of abundant pharmacological agents...
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Intravaginal lactic acid bacteria modulated local and systemic immune responses and lowered the incidence of uterine infections in periparturient dairy cows
Download2015
Dunn, Suzanna M., Odhiambo, John F., Farooq, Umar, Ametaj, Burim N., Lam, Tran, Deng, Qilan
The objective of this investigation was to evaluate whether intravaginal infusion of a lactic acid bacteria (LAB) cocktail around parturition could influence the immune response, incidence rate of uterine infections, and the overall health status of periparturient dairy cows. One hundred pregnant...
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Manipulation of the Angiogenic Balance by Pharmacological Inhibition of Platelet PKC Signalling
DownloadFall 2012
Blood platelets mediate wound healing by preventing bleeding and by supporting growth of new blood vessels. Blood vessel growth is supported in part by growth factors released from platelet α-granules. Both platelet aggregation and α-granule release are mediated by intracellular signaling...
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Fall 2010
Human T-lymphotropic virus type I (HTLV-I) is a persistent human retrovirus characterized by life-long infection and risk of developing HAM/TSP, a progressive neurological and inflammatory disease. Despite extensive studies of HTLV-I, a complete understanding of the viral dynamics has been...
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Mechanisms of Neonatal Intestinal Failure-Associated Liver Disease: Exploring the Gut-Liver Axis
DownloadSpring 2018
Neonates with intestinal failure (IF), who must rely on parenteral nutrition (PN) for growth and maintenance of health, are at risk for intestinal failure-associated liver disease (IFALD). In neonates, short bowel syndrome (SBS) as a result of intestinal resection is the most common cause of IF....
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Novel Mucosal Vaccines to Improve Immune and Health Status of Periparturient Dairy Cows and Increase their Productive Potentials
DownloadFall 2013
The transition period is critical for the health and productivity of dairy cows. Feeding high-grain diets immediately after parturition is necessary to support high milk production. However, high-grain diets are associated with acidic rumen pH and alterations in the composition of rumen...