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A high resolution radiation hybrid map of bovine chromosome 14 identifies scaffold rearrangement in the latest bovine assemblyDownload
Background Radiation hybrid (RH) maps are considered to be a tool of choice for fine mapping closely linked loci, considering that the resolution of linkage maps is determined by the number of informative meiosis and recombination events which may require very large mapping populations....
Associative plasticity and afferent regulation of corticospinal excitability in uninjured individuals and after incomplete spinal cord injuryDownload
Cortical representations are plastic and are allocated based on the proportional use or disuse of a pathway. A steady stream of sensory input maintains the integrity of cortical networks; while in contrast, alterations in afferent activation promote sensorimotor reorganization. After an...
This study examines the problem of belief revision, defined as deciding which of several initially accepted sentences to disbelieve, when new information presents a logical inconsistency with the initial set. In the first three experiments, the initial sentence set included a conditional...
Vitrification of articular cartilage (AC) could enhance tissue availability but requires high concentrations of cyroprotective agents (CPAs). This study investigated relative injuries caused by commonly used CPAs. We hypothesized that the in situ chondrocyte dose–injury relationships of five...
Osteoarthritis is characterized by pain and inflammation in joints, typically weight-bearing joints such as the knee. An early warning sign of osteoarthritis is the loss of proteoglycan molecules in the cartilage matrix. A surrogate method for measuring proteoglycan loss is detection of sodium...
Pitch perception in vocal learners: Fundamental shared components of pitch processing and biological relevanceDownload
Pitch perception is important in both music and language perception in humans. Vocal learners, including humans, share the property of learning their vocalizations from a tutor when young. Similar behavioural and neural mechanisms underlying vocal production among different species of vocal...
In this thesis sensorimotor integration in the human spinal cord was investigated in the intact (Chapters 2 and 3) and injured nervous systems (Chapter 4-stroke; Chapter 5-spinal cord injury (SCI)). In Chapter 2, I characterized a short-latency reflex pathway between sensory receptors of the...
The role of geometric and non-geometric environmental cues in reorientation: Pigeons’ and humans’ use of relative wall lengths, angular information, and featuresDownload
The purpose of the following studies was to explore how humans and pigeons encode and use the geometric and featural information of their environments to orient and navigate. Chapters 1 and 2 examine the use of angular amplitude and relative wall length information in parallelogram-shaped...
Articular cartilage injuries do not heal and large defects result in osteoarthritis with major personal and socioeconomic costs. Osteochondral transplantation is an effective treatment for large joint defects but its use is limited by the inability to store cartilage for long periods of time....
Where electrical stimulation is delivered affects how contractions are generated in the tibialis anterior muscleDownload
This thesis describes experiments designed to investigate how motor units in tibialis anterior (TA) were recruited when electrical stimulation was applied over the TA muscle belly versus the common peroneal nerve trunk. The data from the first study (Chapter 2) showed that contractions were...