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- 1Diether, Natalie E.
- 1Gänzle, Michael G.
- 1Hashemi, Seyede Zohre
- 1Hu, Ying
- 1Ju, Tingting
- 1Li, Jiaying
- 6Graduate Studies and Research, Faculty of
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- 1Agricultural, Food and Nutritional Science, Department of
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Antimicrobial activity of flavan-3-ols and oligomeric proanthocyanidins from pea seed coats and grape seeds against food and gut bacteriaDownload
Proanthocyanidins and their monomeric subunits flavan-3-ols belong to the polyphenol group of flavonoids. They have been proposed to exert health promoting effects against cancer, Type 2 diabetes and coronary disease among other conditions. These health promoting effects are believed to be...
Blood Glucose-attenuating Effects of Pea-derived Fractions: Exploration of Mechanisms of Action in a Rat Model of Glucose IntoleranceDownload
Pulses, including dried peas, are nutrient-dense foods rich in fibre that have shown efficacy in improving glucose control in diabetic subjects. The seed coats, in spite of being the highly fibrous part, are sometimes discarded as a food-processing by-product. We hypothesized that supplementing...
Changes in the gut microbiota have been correlated with positive and negative health outcomes; however, the mechanisms of causality in microbial modifications and resulting host responses are largely unknown. In this thesis, a mouse model was successfully established by colonizing mice with gut...
Effect of Antimicrobial Exposure on Clostridioides difficile (C. difficile) Colonization of the Infant Gut Microbiota in the Canadian Healthy Infant Longitudinal Development (CHILD) Birth CohortDownload
Introduction: Antimicrobial exposure in early life has been associated with gut microbiota dysbiosis and development of allergic diseases in childhood. In adults and older children, C. difficile is the major pathogen responsible for antibiotic-induced diarrhea but the effect of colonization with...
Although genetic factors, diet choices and sedentary lifestyle have long been considered main risk contributors for obesity and diabetes mellitus, years of study show that these factors cannot fully explain the increasing rate of worldwide metabolic disease. Epidemiological studies in recent...
Impaired secretion of insulin from pancreatic beta-cells, along with loss of cell mass, is one of the hallmarks of the pathogenesis of type 2 diabetes, a metabolic disorder characterized by chronic hyperglycemia. In humans, beta-cells’ ability to secrete insulin in response to glucose is acquired...
Protein fermentation by gut microbiota contributes significantly to the metabolite pool in the large intestine and may contribute to host amino acid balance. However, we have a limited understanding of the role that proteolytic metabolites have, both in the gut and in systemic circulation. A...
Prebiotics, FODMAPs and dietary fiber - conflicting concepts in development of functional food products?Download
The term prebiotic relates to beneficial modulation of intestinal microbiota by dietary carbohydrates, however, uncertainties of the differentiation of the term 'prebiotics' from dietary fiber as well as FODMAPs impede development of functional foods containing prebiotics. This communication...