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Skip to Search Results- 1Balutis, Andrea M
- 1Bartusiak, Robert
- 1Bentley, Pamela AP
- 1Blanes, Milena S
- 1Foroutannaddafi, Aidin
- 1Galindo González, Leonardo M
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Fall 2011
Microarrays are biotechnological advancements measuring expressions of thousands of genes in a single assay. A two-group microarray study yields gene expression measurements for patients with a disease of interest and for healthy controls. Our objective is to apply the methods of microarray data...
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Application of Next Generation Sequencing and Bioinformatic Approaches to the Study of Influenza Virus Strains and MiRNA Profiling in Liver Diseases
DownloadSpring 2016
Analysis and interpretation of next generation sequencing data has posed a significant challenge to researchers, especially to those who are not equipped with expertise in bioinformatics. In this thesis, I investigated three different biomedical questions using NGS and bioinformatic approaches,...
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Characterization of Norovirus strains and a seroprevalence study to understand the fluctuation of outbreak activity in Alberta, Canada
DownloadFall 2016
Norovirus (NoV) is recognized as the leading agent causing gastroenteritis among individuals of all ages. Historical data of NoV outbreak surveillance in Alberta, Canada, from the period July 2000 to June 2008 demonstrated a biennial pattern of NoV outbreak activity, in which peaks of high...
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Fall 2014
Optical imaging has long been a gold standard for medical imaging. However, due to the high optical scattering in tissues, it has not been possible to image deeper than a few wavelengths with a useful resolution. Photoacoustic imaging - the use of short-pulsed lasers to induce an ultrasound...
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Combined Assembly of Metagenomic Libraries from The Faecal Samples of IBD and PSC Patients Allowed The Identification of African Swine Fever Virus-like Sequences
DownloadSpring 2015
Metagenomics is an emerging discipline to explore microbial diversity in clinical samples, independent of the limitations of cell cultures. This method is widely accepted as a modern technique to detect novel viruses in clinical and environmental samples and has the potential to contribute to the...
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Detecting, correcting, and preventing the batch effects in multi-site data, with a focus on gene expression Microarrays
DownloadSpring 2014
Gene expression microarrays are widely used to better understand the complex biological mechanisms inside cells. One of the main obstacles of applying statistical learning algorithms to microarray data is the large gap between the number of features (p) and the number of available instances (n),...
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Elucidating the effects of photoperiod during gestation and lactation on mammary gene expression and function in cows and mice
DownloadSpring 2015
Photoperiod, or day length, generates a highly accurate biological calendar that allows animals to anticipate and adapt to environmental change throughout the year. Photoperiod coordinates both daily and yearly rhythms associated with sleep/wake cycles, behavior, and reproduction, including...
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Fall 2012
Sub-acute ruminal acidosis is a digestive disorder experienced by animals fed a high grain diet, and causes substantial economic loss to the dairy industry. The objective of this research was to evaluate novel approaches to manage and prevent sub-acute ruminal acidosis. In Study 1, I found that...
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Spring 2014
Mandatory folate fortification polices in North America have resulted in high levels of circulating folate in the population. At the same time, a trend toward increased energy intake and reduced energy expenditure has lead to an increased prevalence of obesity, characterized by an accumulation of...
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Spring 2014
Adipose tissue plays an important role in the energetic balance, but it is also an important aspect of meat quality and animal productivity. However, the understanding on how fat metabolism is regulated in beef cattle is not clear. This research aimed at exploring how bovine adipose tissue is...