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- 6Gene therapy
- 1Antithrombotic polymers
- 1Cancer--Gene therapy
- 1Cationic polymers
- 1Benjaminy, Shelly
- 1Bubela, Tania
- 1Hsu, Charlie Yu Ming
- 1Meneksedag Erol, Deniz
- 1Miklavcic, John
- 1Morin, Kevin Wayne.
A Combined Computational and Experimental Investigation of Polynucleotide Binding Polymers for Therapeutic ApplicationsDownload
Polynucleotide binding polymers have a wide range of therapeutic applications including delivery systems for therapeutic polynucleotides, and antithrombotic drugs for extracellular nucleic acid-mediated thrombogenic events. This dissertation explores polynucleotide binding polymers in these two...
Ganglioside Increases Metastatic Potential and Susceptibility of Prostate Cancer to Gene Therapy in vitroDownload
Prostate cancer (CaP) is the 2nd most common cancer in North American men. Tumour management strategies are appropriate for early stage disease, but advanced disease has a poor prognosis and requires prompt treatment. Therefore, research into delay of tumour progression and efficacious treatment...
Mechanistic studies on the uptake and intracellular trafficking of DNA complexes in primary cells using lipid-modified cationic polymers as non-viral gene carrierDownload
This thesis work is aimed at addressing some of the fundamental questions surrounding the intracellular fate of plasmid DNA in clinically-relevant primary cells, when delivered with lipid-modi!ed cationic polymers as gene carriers. We developed an optimized procedure for the transfection of...
Ocular Gene Transfer in the Spotlight: Implications of Newspaper Content for Clinical CommunicationsDownload
Background Ocular gene transfer clinical trials are raising hopes for blindness treatments and attracting media attention. News media provide an accessible health information source for patients and the public, but are often criticized for overemphasizing benefits and underplaying risks of novel...