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Subject: Extracellular matrix Item type: Thesis Supervisors: Kassiri, Zamaneh (Physiology)

  • Dual role of matrix metalloproteinases-2 in thoracic aortic aneurysm

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    Spring 2014

    Lee, Ji Won

    With matrix metalloproteinases-2 (MMP2) deficiency, we observed thoracic aortic aneurysm in 70% of MMP2-/- mice but no abdominal aortic aneurysm following four weeks of angiotensin II (Ang II) infusion. We found markedly suppressed recoil properties in the thoracic aorta of MMP2-/-- Ang II mice....

  • The Role of TIMPs in Heart Disease

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    Fall 2012

    Kandalam, Vijay S.

    Heart disease is a leading cause of morbidity and mortality in the world with a growing prevalence in a variety of manifestations. Many of the events that occur in the heart during the progression of disease have been explored to identify a causative mechanism to develop effective treatments and...

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