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- 1Banni, Sebastiano
- 1Curtis, Jonathan M.
- 1Diane, Abdoulaye
- 1Field, Catherine J.
- 1Igarash, Miki
- 1Jacome Sosa, Maria Miriam
Elucidating the roles of endocannabinoid signalling pathway in motor neuron and locomotor development in zebrafish early lifeDownload
The major endocannabinoids (eCBs), anandamide (AEA) and 2-arachidonoylglycerol (2-AG) mediate their effects through their actions on cannabinoid receptors (CBRs), mainly via CB1R and CB2Rs. The predominant catabolic regulators that degrade AEA and 2-AG are fatty acid amide hydrolase (FAAH) and...
Trans-11 Vaccenic Acid Favourably Remodels Whole Body Energy and Endocannabinoid Metabolism During Conditions of DyslipidemiaDownload
Introduction: Trans 11-18:1 (vaccenic acid, VA) is the predominant ruminant-derived trans fatty acid (TFA) in the food chain and is also the precursor to endogenous synthesis of cis-9, trans-11 conjugated linoleic acid (CLA). Literature documents numerous health benefits associated with CLA,...
Vaccenic acid suppresses intestinal inflammation by increasing the endocannabinoid anandamide and non-cannabinoid signaling molecules in a rat model of the metabolic syndromeDownload
Jacome-Sosa, Miriam, Proctor, Spencer D., Field, Catherine J., Vacca, Claudia, Nelson, Randy C., Mangat, Rabban, Reaney, Martin J., Curtis, Jonathan M., Banni, Sebastiano, Diane, Abdoulaye, Piomelli, Daniele, Igarash, Miki, Vine, Donna F., Shen, Jianheng
Vaccenic acid (VA), the predominant ruminant-derived trans fat in the food chain, ameliorates hyperlipidemia, yet mechanisms remain elusive. We investigated whether VA could influence tissue endocannabinoids (ECs) by altering the availability of their biosynthetic precursor, arachidonic acid...