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Phosphatidylethanolamine N-methyltransferase (PEMT), a liver enriched enzyme, is responsible for approximately one third of hepatic phosphatidylcholine (PC) biosynthesis via three sequential methylations of phosphatidylethanolamine (PE). PEMT is also expressed in white adipose tissue (WAT). When...
The Role of Mitochondrial Dynamics on Neurodegenerative Processes of Multiple Sclerosis in Respose to Inflammation and Endoplasmic Reticulum StressDownload
Biopsies and post-mortem tissue of patients with multiple sclerosis (MS) as well as inflammatory demyelinating animal models show that endoplasmic reticulum (ER) stress is a hallmark of the progression of these pathologies. Moreover, MS biopsies and animal models of neuroinflammatory diseases...