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- 7Randomized controlled trials
- 6Systematic reviews
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- 16Medicine and Dentistry, Faculty of
- 16Medicine and Dentistry, Faculty of/Alberta Research Centre for Health Evidence (ARCHE)
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- 7Nursing, Faculty of/Health Systems
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A descriptive analysis of a representative sample of pediatric randomized controlled trials published in 2007
Download2013-02-04
Hamm, Michele, Vandermeer, Ben, Thomson, Denise, Milne, Andrea, Tjosvold, Lisa, Klassen, Terry P., Curtis, Sarah, Hartling, Lisa
BACKGROUND: Randomized controlled trials (RCTs) are the gold standard for trials assessing the effects of therapeutic interventions; therefore it is important to understand how they are conducted. Our objectives were to provide an overview of a representative sample of pediatric RCTs published in...
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A descriptive analysis of child-relevant systematic reviews in the Cochrane Database of Systematic Reviews
Download2013-02-04
Hartling, Lisa, Chisholm, Annabritt, Moher, David, Bow, Simon, Klassen, Terry P., Thomson, Denise, Tjosvold, Lisa, Klassen, Jeffrey
Background: Systematic reviews (SRs) are considered an important tool for decision-making. There has been no recent comprehensive identification or description of child-relevant SRs. A description of existing child-relevant SRs would help to identify the extent of available child-relevant...
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2014
Hamm, M. P., Shulhan, J., Milne, A., Williams, G., Scott, S. D., Hartling, L.
Background: Social media use is highly prevalent among children, youth, and their caregivers, and its use in healthcare is being explored. The objective of this study was to conduct a systematic review to determine: 1) for what purposes social media is being used in child health and its...
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Applying the risk of bias tool in a systematic review of combination long-acting beta-agonists and inhaled corticosteroids for persistent asthma.
Download2011
Seida, J., Vandermeer, B., Hartling, L., Dryden, D. M., Rowe, B. H., Bond, K.
Background The Risk of Bias (RoB) tool is used to assess internal validity of randomized controlled trials (RCTs). Our objectives were to: 1) evaluate inter-rater agreement of the RoB tool; 2) determine the time to access supplemental study information; 3) compare the RoB tool with the Jadad...
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Behavioural and developmental interventions for autism spectrum disorder: a clinical systematic review.
Download2008
Clark, B., Hartling, L., Krebs Seida, J., Karkhaneh, M., Smith, V., Tjosvold, L., Ospina, M. B.
BACKGROUND: Much controversy exists regarding the clinical efficacy of behavioural and developmental interventions for improving the core symptoms of autism spectrum disorders (ASD). We conducted a systematic review to summarize the evidence on the effectiveness of behavioural and developmental...
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Children are not just small adults: the urgent need for high-quality trial evidence in children.
Download2008
Offringa, M., Hartling, L., Craig, J. C., Klassen, T. P.
Children are often touted as being very important members of society because they represent our future. Optimizing their health outcomes has the potential for a huge impact on public health because children are at an early stage in the life trajectory. But it is often unclear how society...
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2005
Swingler, G., Williams, K., Hartling, L., Moyer, V., Cramer, K., Klassen, T. P., Wiebe, N.
Background The delivery of optimal medical care to children is dependent on the availability of child relevant research. Our objectives were to: i) systematically review and describe how children are handled in reviews of drug interventions published in the Cochrane Database of Systematic Reviews...
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Diagnosing Clinically Significant Dehydration in Children with Acute Gastroenteritis Using Noninvasive Methods: A Meta-Analysis
Download2015
Milne, Andrea, Hartling, Lisa, Vandermeer, Ben, Freedman, Stephen B.
OBJECTIVE: To determine the most accurate, noninvasive method of assessing dehydration. STUDY DESIGN: The following data sources were searched: electronic databases, gray literature, scientific meetings, reference lists, and authors of unpublished studies. Eligible studies were comparative...
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Do health care institutions value research? A mixed methods study of barriers and facilitators to methodological rigor in pediatric randomized trials.
Download2012
Scott, S. D., Hamm, M. P., Hartling, L., Klassen, T. P., Moher, D.
Background Pediatric randomized controlled trials (RCTs) are susceptible to a high risk of bias. We examined the barriers and facilitators that pediatric trialists face in the design and conduct of unbiased trials. Methods We used a mixed methods design, with semi-structured interviews building...
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2013
Scott, S. D., Moher, D., Klassen, T. P., Hartling, L., Hamm, M. P.
Introduction A research-practice gap exists between what is known about conducting methodologically rigorous randomized controlled trials (RCTs) and what is done. Evidence consistently shows that pediatric RCTs are susceptible to high risk of bias; therefore novel methods of influencing the...