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Spring 2015
Cholesterol is well known for its adverse cardiovascular effects, however it has crucial cellular roles. For instance, cholesterol is a key component of eukaryotic cell membranes and constitutes the principle steroid hormone precursor in most animals. Cellular cholesterol concentrations have to...
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Examining whether Multicopper Oxidase 4 (Mco4) acts as a high affinity iron importer in Drosophila melanogaster
DownloadFall 2024
Iron is a crucial micronutrient for nearly all living organisms, playing a vital role in various biological processes. In humans, it is essential for the production of hemoglobin, which is necessary for oxygen transport in red blood cells. Beyond oxygen transport, iron is a key component of...
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Genetic, genomic and molecular studies of signaling pathways controlling ecdysone biosynthesis in Drosophila melanogaster
DownloadFall 2013
In insects, periodic pulses of the molting hormone ecdysone control all major developmental transitions such as the molts and metamorphosis. Ecdysone, a steroid hormone, is produced in the prothoracic gland during larval and pupal development of Drosophila. While we have a relatively good...
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Investigating the Nuclear Roles of Iron Regulatory Protein-1A (IRP1A) in Drosophila melanogaster
DownloadFall 2023
Iron is an indispensable micronutrient for almost all organisms. Either the lack or excess of iron can result in various human diseases. Therefore, to maintain cellular iron homeostasis, the IRP/IRE (iron regulatory protein/iron responsive element) system tightly regulates iron concentrations....
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Fall 2022
The ppk20 (pickpocket 20) gene was identified from a two-step screen that was aimed at identifying genes relevant to Drosophila iron and heme homeostasis. Initially, our lab collaborated with two other labs and carried out a prothoracic gland (PG)-specific genome-wide screen of 12,500 RNA...