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- 1 Li, Jun
- 1Abeysundara, Namal W
- 1Androschuk, Alaura MA
- 1Arantes, A. S.
- 1Arnold, Kirsten J
- 1Audibert, A.
- 16Graduate Studies and Research, Faculty of
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- 4Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 1Roy Berg Kinsella Research Ranch
- 1Roy Berg Kinsella Research Ranch/Journal Articles (Kinsella Ranch)
Abstract: A cluster of genes of the CYP6 family was found in a series of overlapping lambda DASH clones from a genomic library of the house fly, Musca domestica, Four complete genes, CYP6A3, CYP6A4, CYP6A5, and CYP6C1, and fragments of two other genes, CYP6A6 and CYP6C2, were closely linked on a...
Cyclin dependent kinase 1, Cdk1, inhibitory phosphorylation is at the core of conserved checkpoint mechanisms that prevent mitosis from interfering with DNA replication or repair. It is also crucial for coordinating cell cycle progression with morphogenetic processes during organismal...
Characterisation of novel potential phosphorylation sites in the tumour suppressor Merlin in DrosophilaDownload
Neurofibromatosis Type II is an inherited cancer that manifests as various tumours in the nervous system. Mutations and deletions in the tumour suppressor Merlin (moesin, ezrin, radixin-like protein) are linked to the development of the disease. The mechanism by which Merlin suppresses cell...
Characterisation of the Non-Canonical Translation Initiation Factor eIF4E-3 as a Merlin Interacting Protein in Drosophila melanogasterDownload
Merlin is a tumour suppressor protein, the loss of which is linked to the inherited nervous system tumour syndrome Neurofibromatosis type 2 as well as sporadic tumour development. It is related to the ERM (ezrin-radixin-moesin) protein family, which is involved in linking the cytoskeleton to...
Merlin and the ezrin-radixin-moesin (ERM) proteins are key organizers of the cell cortex through linking membrane-associated proteins to the underlying actin cytoskeleton. Merlin and the ERM proteins have been implicated in the maintenance of cell integrity, adhesion, and motility during tissue...
Endocycles, which are characterised by repeated rounds of DNA replication without intervening mitosis, are involved in developmental processes associated with an increase in metabolic cell activity and are part of terminal differentiation. Endocycles are currently viewed as a restriction of the...
Cyclic Adenosine Monophosphate (cAMP) and Fragile X Mental Retardation Protein (FMRP) Mediate Avoidance Behaviour in DrosophilaDownload
Fragile X Syndrome (FXS) is neurodevelopmental disorder caused by a trinucleotide CGG repeat expansion that leads to the methylation and transcriptional silencing of the Fragile X mental retardation 1 (fmr1) gene. This results in the loss of Fragile X mental retardation protein (FMRP), an...
Cholesterol is well known for its adverse cardiovascular effects, however it has crucial cellular roles. For instance, cholesterol is a key component of eukaryotic cell membranes and constitutes the principle steroid hormone precursor in most animals. Cellular cholesterol concentrations have to...
Drosophila Mage, a component of Smc5/6 DNA response complex, confers resistance to caffeine and genotoxic stress and plays a role in the cell cycle and cell survivalDownload
Over 50 Melanoma-associated antigen (MAGE) genes have been identified in the human genome. They share a conserved 200 amino acid MAGE-homology domain (MHD). In yeast, the only MAGE homolog (Nse3) is a component of the Smc5/6 DNA damage response complex. In humans, MAGE proteins influence cell...
Expansion of ruminant-specific microRNAs shapes target gene expression divergence between ruminant and non-ruminant speciesDownload
Background Understanding how species-specific microRNAs (miRNAs) contribute to species-specific phenotypes is a central topic in biology. This study aimed to elucidate the role of ruminant-specific miRNAs in shaping mRNA expression divergence between ruminant and non-ruminant species. ...