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Skip to Search Results- 1Abd Elhafiz, Areeg
- 1Abeysundara, Namal W
- 1Anderson-Baron, Matthew N
- 1Androschuk, Alaura MA
- 1Arnold, Kirsten J
- 1Ayeni, Joseph O
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Genetic, genomic and molecular studies of signaling pathways controlling ecdysone biosynthesis in Drosophila melanogaster
DownloadFall 2013
In insects, periodic pulses of the molting hormone ecdysone control all major developmental transitions such as the molts and metamorphosis. Ecdysone, a steroid hormone, is produced in the prothoracic gland during larval and pupal development of Drosophila. While we have a relatively good...
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Spring 2024
To maintain an effective barrier, intestinal epithelial progenitor cells must divide at a rate that matches the loss of dead and dying cells. Epithelial damage during most enteric infection accelerates cell proliferation and tissue repair via multiple stress responses. However, infection with the...
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Spring 2019
Myt1 kinase performs several functions during Drosophila development. Myt1 has firstly been described as a regulator of the G2/M DNA damage checkpoint in the developing wing disc. In addition, Myt1 has been shown to regulate several aspects of male and female gametogenesis, while also...
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Investigating the Nuclear Roles of Iron Regulatory Protein-1A (IRP1A) in Drosophila melanogaster
DownloadFall 2023
Iron is an indispensable micronutrient for almost all organisms. Either the lack or excess of iron can result in various human diseases. Therefore, to maintain cellular iron homeostasis, the IRP/IRE (iron regulatory protein/iron responsive element) system tightly regulates iron concentrations....
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Fall 2022
The ppk20 (pickpocket 20) gene was identified from a two-step screen that was aimed at identifying genes relevant to Drosophila iron and heme homeostasis. Initially, our lab collaborated with two other labs and carried out a prothoracic gland (PG)-specific genome-wide screen of 12,500 RNA...
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Spring 2023
Intestinal epithelial damage and homeostatic cell shedding sends evolutionarily conserved growth signals to activate division programs in stem cells, which renews the epithelium to maintain barrier integrity. In addition to conserved growth and stress signaling, microbes and innate immune...
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Spring 2013
If all cells in a multicellular organism contain exactly the same genetic information, the question arises of how tissue types with distinct gene expression profiles are formed and maintained over the life of the organism. These different temporal and spatial gene expression patterns are thought...
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Fall 2020
Peroxisomes are organelles responsible for processing lipids and managing reactive oxygen species. A conserved family of genes called peroxisome biogenesis factors (Peroxin, Pex) encode proteins necessary for peroxisome biogenesis and function. In yeast and mammals, PEROXIN7 (PEX7) acts as a...
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Spring 2019
Organelles serve to compartmentalize biochemical functions within the eukaryotic cell. However, to collectively maintain cellular homeostasis, organelles must communicate in some way in order to coordinate these functions. Two such organelles,the peroxisome and the lipid droplet, are both...
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Proliferative Signals Regulate Hemocyte Development and Intestinal Immunity in Drosophila melanogaster.
DownloadSpring 2015
The innate immune system is an ancient line of resistance against intrusive microbial threats. This system integrates cellular, humoral, and barrier defenses to generate a protective immune response. These divisions are indispensable and conserved between Drosophila and mammals. Hemocytes are the...