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Skip to Search Results- 1Abd Elhafiz, Areeg
- 1Ayeni, Joseph O
- 1Deng, Hua
- 1Gopalakrishnan, Akila
- 1Liang, Caroline
- 1McCracken, Allen TM
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Fall 2014
Cyclin dependent kinase 1, Cdk1, inhibitory phosphorylation is at the core of conserved checkpoint mechanisms that prevent mitosis from interfering with DNA replication or repair. It is also crucial for coordinating cell cycle progression with morphogenetic processes during organismal...
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Spring 2015
Cholesterol is well known for its adverse cardiovascular effects, however it has crucial cellular roles. For instance, cholesterol is a key component of eukaryotic cell membranes and constitutes the principle steroid hormone precursor in most animals. Cellular cholesterol concentrations have to...
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Spring 2022
Iron is involved in many aspects of life and is essential for survival and normal development. The role of iron in the body is crucial for many processes, including oxygen transport, steroid hormone synthesis, and DNA repair. However, iron transport in Drosophila melanogaster is less...
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Examining whether Multicopper Oxidase 4 (Mco4) acts as a high affinity iron importer in Drosophila melanogaster
DownloadFall 2024
Iron is a crucial micronutrient for nearly all living organisms, playing a vital role in various biological processes. In humans, it is essential for the production of hemoglobin, which is necessary for oxygen transport in red blood cells. Beyond oxygen transport, iron is a key component of...
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Genetic, genomic and molecular studies of signaling pathways controlling ecdysone biosynthesis in Drosophila melanogaster
DownloadFall 2013
In insects, periodic pulses of the molting hormone ecdysone control all major developmental transitions such as the molts and metamorphosis. Ecdysone, a steroid hormone, is produced in the prothoracic gland during larval and pupal development of Drosophila. While we have a relatively good...
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Spring 2019
Myt1 kinase performs several functions during Drosophila development. Myt1 has firstly been described as a regulator of the G2/M DNA damage checkpoint in the developing wing disc. In addition, Myt1 has been shown to regulate several aspects of male and female gametogenesis, while also...
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Investigating the Nuclear Roles of Iron Regulatory Protein-1A (IRP1A) in Drosophila melanogaster
DownloadFall 2023
Iron is an indispensable micronutrient for almost all organisms. Either the lack or excess of iron can result in various human diseases. Therefore, to maintain cellular iron homeostasis, the IRP/IRE (iron regulatory protein/iron responsive element) system tightly regulates iron concentrations....
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Fall 2022
The ppk20 (pickpocket 20) gene was identified from a two-step screen that was aimed at identifying genes relevant to Drosophila iron and heme homeostasis. Initially, our lab collaborated with two other labs and carried out a prothoracic gland (PG)-specific genome-wide screen of 12,500 RNA...
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Spring 2013
If all cells in a multicellular organism contain exactly the same genetic information, the question arises of how tissue types with distinct gene expression profiles are formed and maintained over the life of the organism. These different temporal and spatial gene expression patterns are thought...
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Past, present, and future: Non-consumptive effects of the ectoparasitic mite Macrocheles subbadius on adult and larval Drosophila nigrospiracula
DownloadFall 2024
Parasites can indirectly impact hosts through non-consumptive effects (NCEs) via changes in behaviour, morphology, and/or physiology. These responses can be understood in terms of the ecology of fear framework. My study system involves a cactophilic fruit fly (Drosophila nigrospiracula) and a...