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Promoting Activity Behaviour in Adults with Multiple Sclerosis: Feasibility, Preliminary Efficacy and Evaluation of Activity Measurement Tools
DownloadFall 2021
Background: Multiple sclerosis (MS) is the largest cause of non-traumatic neurological disability in young adults. Canada has one of the highest rates of MS in the world, with nearly 1 in every 385 Canadians living with the disease. People with MS deal with a broad range of symptoms including...
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Spring 2023
Recent thymic emigrants (RTE) are newly generated T cells that have just been exported to the periphery, where they continue their maturation to become mature T cells. RTE have only undergone central tolerance in the thymus but not yet undergone peripheral tolerance. As such, it is imperative...
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Sex Differences in Central Nervous System Plasticity and Pain in Experimental Autoimmune Encephalomyelitis
DownloadSpring 2019
Multiple sclerosis (MS) is a neurodegenerative autoimmune disease with many known structural and functional changes in the central nervous system (CNS). A well-recognized, but poorly understood, complication of MS is chronic pain. Little is known regarding the influence of sex on the development...
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The Effect of Dopamine on Pulmonary Diffusing Capacity and Capillary Blood Volume Responses to Exercise
DownloadFall 2017
Pulmonary diffusing capacity increases during exercise to meet the increasing oxygen (O2) demand of the body. Expansion of pulmonary capillary blood volume (Vc) and diffusing membrane capacity (Dm) are important contributors to the increased diffusing capacity observed during upright cycle...
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The pulmonary vasculature during exercise in health and mild chronic obstructive pulmonary disease
DownloadFall 2017
The purpose of this dissertation was to characterize the response of the pulmonary vasculature to exercise in health (including a pharmacological intervention) and in individuals with mild chronic obstructive lung disease. The first project studied the effect of a dopamine receptor blockade on...
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Spring 2017
MS is a chronic demyelinating disease of the CNS that presents with debilitating symptoms in the later stages of disease progression and therefore a high demand for targeted disease-modifying treatments exists. In order to create effective treatments the causalities between the symptoms and...
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γ-Aminobutyric Acid Up-Regulates the Expression of a Novel Secretogranin-II Messenger Ribonucleic Acid in the Goldfish Pituitary
Download1998
Docherty, K., Chang, J.P., Blázquez, M., Trudeau, V.L., Bosma, P.T.
An RNA-arbitrarily primed PCR differential display strategy was used to identify candidate genes in the pituitary that are up-regulated by endogenously activated g-aminobutyric acid (GABA) systems that may also be involved in the control of reproduction. Goldfish were injected with the GABA...