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Spring 2015
Besides being the most popular drug in the world, caffeine is an attractive tool used in research to help us answer fascinating scientific questions, because caffeine impinges on a number of molecular pathways. In my research, I used caffeine to study DNA repair pathways and insect xenobiotic...
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Spring 2013
If all cells in a multicellular organism contain exactly the same genetic information, the question arises of how tissue types with distinct gene expression profiles are formed and maintained over the life of the organism. These different temporal and spatial gene expression patterns are thought...
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Spring 2010
Development of the vertebrate central nervous system is a complex process that relies on the accurate spatiotemporal distribution of signaling centers during embryogenesis. These signals provide cells with positional information, which is integrated via transcription factors and gene regulatory...
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Fall 2018
Early mammalian development cannot progress without targeted temporal and spatial expression of genes. Changing the accessibility of DNA to transcriptional machinery is one critical way gene expression is controlled. This process, known as chromatin remodeling, is vital for formation of the...
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The roles of Pbx and Meis TALE-class homeodomain transcription factors in vertebrate neural patterning
DownloadFall 2010
One of the major goals of developmental biology is to understand how specialized groups of cells arise from an initially unspecified cell population. The vertebrate hindbrain is transiently segmented along its anterior-posterior axis into lineage-restricted compartments called rhombomeres, making...