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Computational identification of residues that modulate voltage sensitivity of voltage-gated potassium channels
Download2005
Background: Studies of the structure-function relationship in proteins for which no 3D structure is available are often based on inspection of multiple sequence alignments. Many functionally important residues of proteins can be identified because they are conserved during evolution. However,...
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Endogenous melanocortin antagonist in fish: Structure, brain mapping and regulation by fasting of the goldfish agouti-related protein gene
Download2003
Cerdá-Reverter, J.M., Peter, R.E.
Agouti-related protein (AGRP) is a naturally occurring antagonist of melanocortin. In mammals, central AGRP expression is restricted to the arcuate nucleus in which it plays a key role in the control of energy balance by antagonizing melanocortin effects at melanocortin 4 receptors. In goldfish,...
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Generation of a restriction minus enteropathogenic Escherichia coli E2348/69 strain that is efficiently transformed with large, low copy plasmids
Download2008
Raivio, T.L., Price, N.L., Ward, J.D., Hobson, N.
Background Many microbes possess restriction-modification systems that protect them from parasitic DNA molecules. Unfortunately, the presence of a restriction-modification system in a given microbe also hampers genetic analysis. Although plasmids can be successfully conjugated into the...
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GERp95, a membrane-associated protein that belongs to a family of proteins involved in stem cell differentiation
Download1999
DiMattia, G.E., Hansen, D., Tahbaz, N., Hobman, T.C., Hendricks, L.C., Pilgrim, D., Cikaluk, D.E.
A panel of mAbs was elicited against intracellular membrane fractions from rat pancreas. One of the antibodies reacted with a 95-kDa protein that localizes primarily to the Golgi complex or the endoplasmic reticulum (ER), depending on cell type. The corresponding cDNA was cloned and sequenced and...
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1987
Owttrim, George W., Coleman, John R.
A recA-like gene isolated from the cyanobacterium Anabaena variabilis was cloned and partially characterized. When introduced into Escherichia coli recA mutants, the 7.5-kilobase-pair plasmid-borne DNA insert restored resistance to methyl methanesulfonate and UV irradiation, as well as...
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Molecular cloning, pharmacological characterization and brain mapping of the melanocortin 4 receptor in the goldfish: Involvement in the control of food intake
Download2003
Schioth, H.B., Cerdá-Reverter, J.M., Peter, R.E., Ringholm, A.
We report cloning, pharmacological characterization, tissue distribution, detailed brain mapping, and role in control of food intake of melanocortin 4 receptor in goldfish (gMC4R). The gMC4R protein has 68% identity with the human ortholog and is conserved in important functional domains....