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Biochemical investigations of two polyketide synthase subclasses – highly reducing/non-reducing pairs, and polyketide synthase non-ribosomal peptide synthetases.
DownloadSpring 2016
Cladosporin is a polyketide metabolite that is biosynthesized by a highly reducing (HR)/non-reducing (NR) polyketide synthase (PKS) pair, wherein they catalyse head-totail condensation of acetyl and malonyl CoA units with subsequent β-keto modification. Cladosporin has recently been reported as a...
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Syntheses of Probes for the Elucidation of Biosynthetic Pathways and Interactions of Natural Products
DownloadFall 2018
A new platform for the semi-synthetic preparation of a known nanomolar inhibitor of the Plasmodium falciparum lysyl-tRNA synthetase, cladosporin, from Cladosporium cladosporioides and its analogues was developed. Our work has shown that it is produced biosynthetically by a highly reducing (HR)...