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Skip to Search Results- 2Chronic Obstructive Pulmonary Disease
- 1Antioxidants
- 1Cardiovascular Function
- 1Dimers (Chemical Physics)
- 1Dyspnea
- 1Immunoblotting
- 1Barnes, Peter J.
- 1Curtis, Jonathan M.
- 1Ito, Kazuhiro
- 1Kimura, Genki
- 1Kizawa, Yasuo
- 1Mercado, Nicolas
- 1Agricultural, Food and Nutritional Science, Department of
- 1Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 1Graduate and Postdoctoral Studies (GPS), Faculty of
- 1Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
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Activation of transcription factor Nrf2 signalling by the sphingosine kinase inhibitor SKI-II is mediated by the formation of Keap1 dimers
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Ueda, Keitaro, Ito, Kazuhiro, Kimura, Genki, Moses, Audric, Xiong, Yeping, Kizawa, Yasuo, Curtis, Jonathan M., Barnes, Peter J., Mercado, Nicolas
Anti-oxidant capacity is crucial defence against environmental or endogenous oxidative stress. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that plays a key defensive role against oxidative and cytotoxic stress and cellular senescence. However, Nrf2...
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Spring 2020
The purpose of this dissertation was to investigate cardiovascular function and ventilatory regulation at rest and during exercise in patients with chronic obstructive pulmonary disease (COPD). This dissertation consisted of three separate experiments that aimed to provide insight into the...