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Spring 2012
In Pulmonary Arterial Hypertension (PAH), pro-constrictive, pro-proliferative and anti-apoptotic diatheses converge to produce contraction and excessive proliferation of pulmonary artery smooth muscle cells (PASMC), a hallmark of PAH-vascular remodeling. The increased afterload causes right...
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Molecular and cellular roles of the N-end rule pathway in apoptotic cell death in mammalian-derived cell lines
DownloadFall 2017
Cellular stresses and signaling that lead to the initiation of apoptotic pathways often result in the activation of proteases such as caspases which in turn culminate in the generation of proteolytically activated protein fragments with new or altered roles. Recent work has revealed that the...
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MOLECULAR AND PHENOTYPIC CHARACTERIZATION OF DISTINCT BREAST CANCER CELL SUBPOPULATIONS PURIFIED USING A SOX2 REGULATORY REGION 2 TRANSCRIPTION ACTIVITY REPORTER
DownloadFall 2015
Sex-determining Region Y-box 2 (Sox2) is a transcription factor integral to the maintenance of pluripotency in embryonic stem cells. In recent years, Sox2 expression has been detected and implicated in the pathogenesis of breast and other cancers. Clinically, Sox2 expression has been associated...
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Fall 2012
Despite originally being described as a secreted protease, matrix metalloproteinase‐2 (MMP‐2) was recently revealed to have targets within cardiomyocytes. The biological mechanism(s) that describes the intracellular localization of MMP‐2 is unknown and is thus the subject of this thesis....
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Fall 2011
Taxanes are used for the treatment of breast, ovarian, and lung cancer. Unfortunately, taxane based therapy—the current treatment for metastatic breast cancer—has substantial shortcomings including myelosupression, neurotoxicity, and frequently acquired resistance. Our present understanding of...
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Fall 2011
Taxanes are used for the treatment of breast, ovarian, and lung cancer. Unfortunately, taxane based therapy—the current treatment for metastatic breast cancer—has substantial shortcomings including myelosupression, neurotoxicity, and frequently acquired resistance. Our present understanding of...
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Targeting Phosphatidylserine for Positron Emission Tomography Imaging of Cell Death: Annexin V versus Phosphatidylserine-Binding Peptides
DownloadSpring 2016
There is currently no clinically approved, widely used molecular imaging agent for in vivo detection of cell death. Such an agent would be highly useful for early assessment of treatment efficacy in cancer patients, as well as for monitoring many other diseases in which cell death plays an...