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16R-HETE and 16S-HETE Alter Human Cytochrome P450 1B1 through Transcriptional and Allosteric Mechanism
DownloadFall 2022
Cardiac hypertrophy is a complex anomaly of the heart associated with increased muscle mass and thickening of the cell walls in response to accumulative stress. Although this condition occurs naturally, the prolonged state will progress into heart failure or even cause death. Recent studies have...
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Role of A Disintegrin and Metalloproteinases (ADAMs)- 15 and 17 in Cardiac Remodelling Following Pressure Overload
DownloadSpring 2024
Myocardial remodeling is a critical process in response to cardiac stress or injury, which includes changes in the cardiomyocyte size, the extracellular matrix (ECM), and cell-ECM interactions. Cardiac hypertrophy is the morphological increase in the myocardial mass by an increase in the...
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The effect of fluconazole on cytochrome P450 1B1, formation of arachidonic acid metabolites, and protection against angiotensin II-induced cardiac hypertrophy
DownloadFall 2018
Several studies have elucidated the role of cytochrome P450s (CYPs) and their associated arachidonic acid (AA) metabolites in development of cardiac hypertrophy. CYP1B1 has been reported to have a major role in metabolizing AA into cardiotoxic metabolites, mid-chain hydroxyeicosatetraenoic acid...
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Fall 2017
The adipocyte-derived lipokine, C16:1n7-palmitoleate, regulates a variety of functions such as systemic glucose and fatty acid metabolism. Under normal physiological conditions, palmitoleate levels are regulated by de novo lipogenesis. During pathological conditions where there are enhanced rates...
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The Role of Subterminal Hydroxyeicosatetraenoic Acids in the Pathogenesis of Cardiac Hypertrophy
DownloadFall 2021
Cardiac hypertrophy is a complex condition which is characterized by increased mass of the heart muscle. If untreated, cardiac hypertrophy can ultimately lead to heart failure (HF), arrhythmia and sudden death. Accumulating evidence suggest that pathological cardiac hypertrophy is strongly...
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Fall 2010
The mammalian Na+/H+ exchanger isoform 1 (NHE1) is a ubiquitously expressed membrane protein that regulates intracellular pH. In the myocardium, NHE1 has been implicated in ischemia/reperfusion (I/R) and cardiac hypertrophy (CH). Hormonal, autocrine and paracrine stimuli, acidosis, cardiotoxic...