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Skip to Search Results- 17Graduate and Postdoctoral Studies (GPS), Faculty of
- 17Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 1Agricultural, Food and Nutritional Science, Department of
- 1Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 1Medicine and Dentistry, Faculty of
- 1Medicine and Dentistry, Faculty of/Journal Articles (Medicine and Dentistry)
- 4Department of Medicine
- 3Centre for Neuroscience
- 2Department of Physiology
- 1Department of Medical Sciences
- 1Department of Pharmacology
- 1Faculty of Nursing
- 1Colbourne, Fred (Neuroscience)
- 1Colbourne, Frederick (Psychology)
- 1Davidge, Sandra T. (Physiology/Obstetrics and Gynecology)
- 1Dr. Gavin Oudit, Department of Physiology and Department of Medicine
- 1Dyck, Jason RB (Pediatrics)/ McAlister, Finlay A (Medicine)
- 1Haennel, Bob (Faculty of Rehabilitation Medicine)
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A Novel Comparative Analysis Approach to Personalize Chemotherapy Dose Calculation in Early Breast Cancer
DownloadFall 2018
Background Worldwide, body surface area [BSA] is used to calculate chemotherapy dose. The BSA formula was originally developed in 1916, derived from height and weight, with no consideration of other patient characteristics. Most chemotherapy agents have a narrow therapeutic index and are...
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Cardiomyocyte overexpression of iNOS in mice results in peroxynitrite generation, heart block, and sudden death
Download2002-01-01
Mungrue, Imran N., Gros, Robert, You, Xiaomang, Pirani, Asif, Azad, Azar, Csont, Tamas, Husain, Mansoor, Schulz, Richard
Increased inducible nitric oxide synthase (iNOS) expression is a component of the immune response and has been demonstrated in cardiomyocytes in septic shock, myocarditis, transplant rejection, ischemia, and dilated cardiomyopathy. To explore whether the consequences of such expression are...
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Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic Sclerosis
DownloadFall 2023
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
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Spring 2012
Stroke, a reduction in blood flow to the brain, activates various proteins that contribute to neuronal death. The matrix metalloproteinases (MMPs), specifically MMP2 and MMP9, are important in maintaining the blood brain barrier (BBB). After a stroke the BBB permeability increases which is...
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Fall 2016
Multiple sources suggest that insulin resistance and derangements of cardiac metabolism are among the earliest signs of type-2 diabetes detected in the heart. Unfortunately, limited evidence reflects early changes in cardiac mitochondrial metabolism linked to the development of this disease....
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2012
Steele, Michael A., Fisher, Rebecca E., Karrow, Niel A.
Adverse uterine environments experienced during fetal development can alter the projected growth pattern of various organs and systems of the body, leaving the offspring at an increased risk of metabolic disease. The thrifty phenotype hypothesis has been demonstrated as an alteration to the...
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Fall 2022
Background: Although pediatric heart transplantation is a life-saving and effective therapy for children with cardiac disease, barriers remain due to a lack of available organs as well as transplant failure due to rejection. This dissertation aimed to increase knowledge related to immune risk...
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Influence of therapeutic hypothermia on neuroprotection and post-ischemic plasticity in a rat model of global ischemia
DownloadFall 2011
Blood flow to the brain may be disrupted by either a stroke (such as focal ischemia or hemorrhage) or cardiac arrest, where the whole brain becomes ischemic. Both forms of injury result in irreversible neuronal loss leading to neurological impairments and a decrease in the quality of life....
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Intracortical administration of pleiotrophin in ischemic stroke: investigating functional outcomes and glial expression
DownloadSpring 2023
Ischemic stroke is the leading cause of disability and third leading cause of death in Canada, exerting a serious burden on stroke survivors, their families, and healthcare resources. Characterized by brain damage due to loss of blood flow and oxygen supply, ischemic stroke is characterized by...
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Investigating Myocardial PI3Kα Signaling in Models of Ischemia Reperfusion and Cardiotoxic Cancer Therapies
DownloadSpring 2017
Background. Phosphoinositide 3-kinase (PI3K) is a lipid kinase that functions as a central intracellular signaling transduction node, receiving input from cell receptors and initiating a cascade of cellular signaling that regulates and integrates central cellular processes such as glucose uptake,...