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Skip to Search Results- 1Akhnokh, Maria Kodsy
- 1Asomaning, Justice
- 1BATCHU, SRI NAGARJUN
- 1Bai, Helin Daniel
- 1Bosnjak, Natasa
- 1Brophy, Taylor Raymond
- 13Department of Agricultural, Food, and Nutritional Science
- 6Department of Medicine
- 6Faculty of Pharmacy and Pharmaceutical Sciences
- 5Department of Biochemistry
- 5Department of Biological Sciences
- 4Department of Medical Microbiology and Immunology
- 2Foley, Edan (Medical Microbiology and Immunology)
- 2Lemire, Bernard (Biochemistry)
- 2Nargang, Frank (Biological Sciences)
- 1Ambrose, Divakar (Department of Agricultural, Food and Nutritional Science)
- 1Backhouse, Christopher J. (Electrical and Computer Engineering)
- 1Baker, Kristi (Oncology)
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Regulation of Anti-tumor Immunity in Colorectal Cancer by Interaction of Exosome Immune Complexes with Fc gamma Receptors
DownloadSpring 2019
Targeted therapy is difficult for colorectal cancer (CRC) due to lack of conserved tumor associated antigens (TAA). Immunotherapies for CRC directed at TAA that can overcome intestinal tolerance need to be developed to improve survival of CRC patients. Exosomes are extracellular vesicles secreted...
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A Novel Comparative Analysis Approach to Personalize Chemotherapy Dose Calculation in Early Breast Cancer
DownloadFall 2018
Background Worldwide, body surface area [BSA] is used to calculate chemotherapy dose. The BSA formula was originally developed in 1916, derived from height and weight, with no consideration of other patient characteristics. Most chemotherapy agents have a narrow therapeutic index and are...
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Spring 2014
The TOB (Topogenesis of Outer membrane β-barrel proteins) complex is composed of the core proteins Tob55 (Sam50), Tob37 (Sam37) and Tob38 (Sam35). The complex facilitates the insertion of all β-barrel and some α-helically anchored integral proteins into the mitochondrial outer membrane (MOM)....
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Spring 2010
Cost-effective processing of dairy whey permeates is important to the environment and economics of the agriculture industry in Canada. Bioconversion of whey permeates is an attractive means of obtaining value-added adjuncts with improved nutritional and functional properties. In the past,...
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Body Composition Assessment in Pediatric Obesity: Reliability, Validity, and Clinical Applications
DownloadFall 2020
Adipose tissue and skeletal muscle have unique metabolic roles. Despite body mass index for age and sex (BMI z-score) being historically widely used to evaluate and monitor health status in children with obesity, it does not depict adiposity and muscularity (or their changes) during growth or...
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Characterization of the Mitochondrial Phenotype Associated with Primary Biliary Cholangitis
DownloadSpring 2017
Primary Biliary Cholangitis (PBC) is a chronic liver disease characterized by the immune-mediated destruction of intra-hepatic bile ducts. The autoimmune nature of PBC involves humoral and cell-mediated responses that target endogenous mitochondrial proteins. It is thought that the breakdown of...
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Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic Sclerosis
DownloadFall 2023
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
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Fall 2009
The analysis of wide-angle cellular light scattering patterns is a challenging problem. Small changes to the organization, orientation, shape, and optical properties of scatterers and scattering populations can significantly alter their complex two-dimensional scattering signatures. Because of...