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Skip to Search Results- 1Al Lawati, Hanan M
- 1Asghar, Muhammad Waheed
- 1Asomaning, Justice
- 1Azad, Abul K
- 1Baskar Jesudasan, Sam Joshva
- 1Benson, Curtis A
- 14Department of Agricultural, Food, and Nutritional Science
- 7Department of Medicine
- 6Faculty of Pharmacy and Pharmaceutical Sciences
- 5Centre for Neuroscience
- 5Department of Biological Sciences
- 4Department of Oncology
- 2Foley, Edan (Medical Microbiology and Immunology)
- 2Jamali, Fakhreddin (Faculty of Pharmacy and Pharmaceutical Sciences)
- 2Kerr, Bradley (Anesthesiology and Pain Medicine)
- 1Ambrose, Divakar (Department of Agricultural, Food and Nutritional Science)
- 1Bajzar, Laszlo (Pediatrics)
- 1Baker, Glen (Psychiatry)
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A Novel Comparative Analysis Approach to Personalize Chemotherapy Dose Calculation in Early Breast Cancer
DownloadFall 2018
Background Worldwide, body surface area [BSA] is used to calculate chemotherapy dose. The BSA formula was originally developed in 1916, derived from height and weight, with no consideration of other patient characteristics. Most chemotherapy agents have a narrow therapeutic index and are...
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Altered ganglioside metabolism in inflammatory bowel disease and the impact of dietary ganglioside intake
DownloadFall 2014
Gangliosides are integral to the structure and function of the plasma membrane. Ganglioside composition of the small intestinal brush border membrane and apical surface of the colon influence numerous cell processes including microbial attachment, cell division, differentiation, and signaling....
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Fall 2016
Crohn’s disease (CD) is one of the chronic inflammatory bowel diseases (IBD) with a complex etiology involving genetic factors, priming by enteric microflora, environmental factors and a change in the immune-mediated response, the other IBD is ulcerative colitis. The diagnosis of CD has...
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Spring 2010
Cost-effective processing of dairy whey permeates is important to the environment and economics of the agriculture industry in Canada. Bioconversion of whey permeates is an attractive means of obtaining value-added adjuncts with improved nutritional and functional properties. In the past,...
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Fall 2010
Abstract: Introduction: Partial bladder outlet obstruction (pBOO) is a ubiquitous problem that results in renal damage. We hypothesize that change in the bladder progresses over time. Methods: Fischer rats underwent surgical pBOO for 2, 4, 8, or 13 weeks and were compared to shams. Urodynamic...
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Body Composition Assessment in Pediatric Obesity: Reliability, Validity, and Clinical Applications
DownloadFall 2020
Adipose tissue and skeletal muscle have unique metabolic roles. Despite body mass index for age and sex (BMI z-score) being historically widely used to evaluate and monitor health status in children with obesity, it does not depict adiposity and muscularity (or their changes) during growth or...
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Spring 2017
Characterization of Spinal Cord Microglia. Previous studies suggest that the functional response properties of activated brain microglia varied according to the brain region they were derived from, suggesting that these activation profiles are a function of their local environment. CNS microglia...
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Characterization of the Mitochondrial Phenotype Associated with Primary Biliary Cholangitis
DownloadSpring 2017
Primary Biliary Cholangitis (PBC) is a chronic liver disease characterized by the immune-mediated destruction of intra-hepatic bile ducts. The autoimmune nature of PBC involves humoral and cell-mediated responses that target endogenous mitochondrial proteins. It is thought that the breakdown of...
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Spring 2011
Niemann-Pick Type C (NPC) disease is an autosomal recessive disorder that results in accumulation of unesterified cholesterol in late endosomes/lysosomes (LE/Ls), leading to progressive neurodegeneration and premature death. Microglia are resident immune cells of the central nervous system, which...