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Skip to Search Results- 24Graduate and Postdoctoral Studies (GPS), Faculty of
- 24Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 11Biological Sciences, Department of
- 11Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 3Agricultural, Food and Nutritional Science, Department of
- 3Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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(RADA)4 Self-Assembling Peptide based Hydrogels: Design, Characterization and In-Vitro Biological Evaluation
DownloadFall 2016
Ionic self-assembling peptides have emerged as promising nano-biomaterials, with direct applications in the fields of bioengineering and applicative medicine. (RADA)4 is a self-assembling 16 residue containing peptide, with alternating hydrophobic and hydrophilic residues. This characteristic...
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Assessment of the mechanisms exerting glucose-lowering effects of dried peas in glucose-intolerant rats
Download2012
Jin, Alena, Field, Catherine J., Yee, Homun, Kozicky, Lisa, Morris, Jill, Chan, Catherine B., Bell, Rhonda C., Ha, Christine, Whitlock, Kevin A., Ozga, Jocelyn A.
The present study compared the effects of feeding uncooked pea fractions (embryo v. seed coat) on glucose homeostasis in glucose-intolerant rats and examined potential mechanisms influencing glucose homeostasis. Rats were made glucose intolerant by high-fat feeding, after which diets containing...
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Characterization of the Type VI Secretion System in the Bacterial Pathogen Acinetobacter baumannii
DownloadFall 2016
Antibiotic resistant bacteria that cause hospital-acquired infections are a mounting concern for healthcare systems globally. Multidrug resistant (MDR) Acinetobacter baumannii has emerged as a common cause of nosocomial infections, and some isolates are now pandrug resistant. These infections can...
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Corynebacterium glutamicum: A Platform For Studying Actinobacterial Protein-O-Mannosylation And High-Yield Heterologous Protein Production
DownloadSpring 2024
Corynebacterium glutamicum ATCC 13032 is a generally regarded as safe (GRAS) soil actinobacterium that is widely utilized in industry and was originally used for the large-scale production of amino acids. Through both genetic and metabolic engineering, the organism has been developed into a...
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Design, Synthesis and Evaluation of Cancer Targeting α-Peptides and Novel Peptidomimetic β-Peptides
DownloadFall 2010
Current cancer therapies have low specificity for tumor cells and have serious toxic side effects. Targeting drugs to the cancer cells can help improve the outcome of existing cancer therapies. In recent years, a number of peptides have been identified by peptide phage display for targeting...
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Designed zinc finger proteins as novel therapeutics inhibiting the transcription of hepatitis B and duck hepatitis B viruses
DownloadFall 2010
The Hepatitis B virus (HBV) chronically infects 350 million individuals worldwide, leading to mortality by end-stage liver disease, liver cirrhosis, and hepatocellular carcinoma. The vaccine to prevent HBV infection is highly effective but is not extensively available in endemic areas, resulting...
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Development and Application of Protected Amino Acids for the Installation of Stable Post-translational Modifications Using Solid-Phase Peptide Synthesis
DownloadFall 2022
This thesis describes the synthesis of non-canonical amino acid building blocks and their use in solid-phase peptide synthesis (SPPS) to explore peptidic drug analogues based on natural products. We replaced sensitive functionalities found in the structure of naturally produced peptides with...
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Development of polymer and lipid based nano-delivery systems for targeted cancer chemotherapy
DownloadFall 2012
Conventional chemotherapy agents can kill tumor cells and inhibit tumor growth, but they produce severe side effects on normal cells at the same time. To shift the balance towards tumoral effects, it would be desirable to direct the anti-cancer drug towards tumor while restricting drug access to...