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Skip to Search Results- 5Cancer stem cells
- 3MiRNA
- 3Tumor suppressor
- 2Esophageal squamous cell carcinoma
- 2Sox2
- 1A549 Human Lung Carcinoma Cell Line
- 1Alaee, Mahsa
- 1Alshareef, Abdulraheem
- 1Armstrong, Stephen, R.
- 1Jung, Karen KT
- 1Lin, Zhen
- 1Romao, Josue M
- 2Lai, Raymond (Laboratory Medicine and Pathology)
- 1Abdulkarim, Bassam (Oncology)
- 1Gamper, Armin (Oncology)
- 1Guan, Leluo (Department of Agricultural, Food, and Nutritional Science, University of Alberta)
- 1Jurasz, Paul (Pharmacy and Pharmaceutical Sciences)
- 1Leng, Roger (Laboratory Medicine and Pathology)
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Application of Next Generation Sequencing and Bioinformatic Approaches to the Study of Influenza Virus Strains and MiRNA Profiling in Liver Diseases
DownloadSpring 2016
Analysis and interpretation of next generation sequencing data has posed a significant challenge to researchers, especially to those who are not equipped with expertise in bioinformatics. In this thesis, I investigated three different biomedical questions using NGS and bioinformatic approaches,...
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Deciphering the molecular mechanisms underlying the pathobiology of esophageal squamous cell carcinoma
DownloadFall 2015
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers worldwide, largely due to a high frequency of tumor invasion/metastasis, chemoresistance and recurrence. In this study, we explored from different perspectives the molecular mechanisms behind these aggressive features of...
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Delineating the biology of Anaplastic Lymphoma Kinase (ALK) and its resistance to crizotinib
DownloadFall 2017
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase receptor that was initially identified as a potent oncogenic driver in anaplastic large-cell lymphoma (ALCL) in the form of NPM-ALK fusion protein. Various forms of oncogenic ALK proteins have been identified, subsequently, in various...
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Spring 2014
Adipose tissue plays an important role in the energetic balance, but it is also an important aspect of meat quality and animal productivity. However, the understanding on how fat metabolism is regulated in beef cattle is not clear. This research aimed at exploring how bovine adipose tissue is...
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MOLECULAR AND PHENOTYPIC CHARACTERIZATION OF DISTINCT BREAST CANCER CELL SUBPOPULATIONS PURIFIED USING A SOX2 REGULATORY REGION 2 TRANSCRIPTION ACTIVITY REPORTER
DownloadFall 2015
Sex-determining Region Y-box 2 (Sox2) is a transcription factor integral to the maintenance of pluripotency in embryonic stem cells. In recent years, Sox2 expression has been detected and implicated in the pathogenesis of breast and other cancers. Clinically, Sox2 expression has been associated...
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Molecular Characterization of the Tumor and Metastasis Suppressor Activity of Plakoglobin in Mutant p53 Expressing Carcinoma Cells
DownloadFall 2018
Plakoglobin (γ-catenin) is an Armadillo protein family member and a paralog of β-catenin with similar dual cell-cell adhesion and signaling activities. These proteins interact with cadherins at the membrane and mediate cell-cell adhesion. In the cytoplasm, they interact with an array of cellular...
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Fall 2019
Within a tumour, only a subset of cells are able to initiate neoplasms when transplanted or following localization to different organs. These tumour-initiating cells, often called cancer stem cells (CSCs) due to their high cellular plasticity, were found to exhibit particular resistance to...
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Fall 2016
The p53 family of tumor suppressors is an important group of transcription factors preventing the development of cancer by targeting cell-cycle arrest and apoptosis mediator proteins for transcription. The most studied, p53, is frequently inactivated in carcinomas by mutation or genetic...
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The biological function and clinical significance of STAT1 in esophageal squamous cell carcinoma
DownloadFall 2016
Although esophageal cancer makes up only 1% of all the cancers in western countries, it is a common death cancer in other areas, especially China. Esophageal squamous cell carcinoma (ESCC) is the most common type of esophageal cancer in Chaoshan, an area with high incidence rate of this disease...
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Fall 2016
Background: The cancer stem cell (CSC) theory suggests there are small populations of cancer cells that has stem cell-like characteristics, such as self-renewal. These CSCs are thought to be responsible for initiating new tumors following metastasis. Platelets have also been implicated in cancer...