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Skip to Search Results- 5Cell migration
- 3Calcineurin
- 2Calpain
- 1Atherosclerosis--Animal models
- 1BFABP
- 1Brain fatty acid-binding protein
- 1Brown, Amanda J.
- 1Brun, Miranda
- 1Heisler, Owen Robert.
- 1Jia, Feng
- 1Mullaly, Sarah Catherine.
- 1Raszek, Mikolaj
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Fall 2019
Glioblastoma (GBM), classified as WHO grade IV astrocytoma, is the most common and lethal adult primary brain tumour. Despite recent advances in treatment, GBM prognosis remains largely unchanged with most patients succumbing to the disease within ~15 months of diagnosis. This dismal outcome can...
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Fall 2015
Malignant glioma (MG), comprised of grade III (anaplastic astrocytoma) and grade IV (glioblastoma) astrocytoma, is the most common adult brain tumour, with an incidence of ~4 in 100 000 people. Despite aggressive treatment with surgery, radiation, and chemotherapy, survival remains dismal, with...
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Study of calcineurin interaction with inhibitor-1 and natural products. Towards novel calcineurin inhibitors
DownloadSpring 2012
Calcineurin (CaN) is an eukaryotic Ser/Thr protein phosphatase that plays an important role in lymphocyte activation. Inhibition of CaN leads to immune system suppression, a necessary procedure in organ transplantation. However, use of CaN inhibitors results in toxic side effects. The search for...
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The human neuraminidase enzyme, NEU3, regulates integrin-mediated cell migration via changes in glycolipid composition
DownloadFall 2013
The human neuraminidase enzyme, NEU3, is known to cleave sialic acid from ganglioside substrates. However, the biological effects of this cleavage are not clearly understood. This thesis describes our studies of the regulation of β1-integrins by neuraminidase enzymes, and the role of gangliosides...