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Spring 2023
Prion diseases are rare and fatal neurodegenerative disorders caused by the misfolding of the cellular prion protein (PrPC) to its infectious form (PrPSc). Until recently, the structure of PrPSc was a subject of much debate as there is evidence to support both the 4-rung β-solenoid model and...
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Fall 2022
Prion diseases are neurodegenerative disorders that arise from the misfolding of the cellular prion protein (PrPC) into the infectious prion protein (PrPSc), resulting in a conformational change in the protein structure. Despite being extensively studied, high-resolution structural information...