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Skip to Search Results- 5Wu, Jianping
- 4Chakrabarti, Subhadeep
- 3Majumder, Kaustav
- 3Proctor, Spencer D.
- 2AlZahal, Ousama
- 2Davidge, Sandra T.
- 43Graduate and Postdoctoral Studies (GPS), Faculty of
- 43Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 17Agricultural, Food and Nutritional Science, Department of
- 17Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 3Medicine and Dentistry, Faculty of
- 2Pharmacy and Pharmaceutical Sciences, Faculty of
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Drug-disease interaction: effect of inflammation on the pharmacological response to calcium channel blockers
DownloadFall 2010
The present research is focused on the topic of inflammation-drug interaction. Inflammation complicates many human diseases and conditions ranging from obesity to cancer. Therefore, the study of the effect of inflammation on drug pharmacokinetics and pharmacodynamics is pivotal. First, we tested...
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Effects of aerobic training on the host systemic milieu in patients with solid tumors: An exploratory correlative study
Download2015
Stevens, Robert D., Courneya, Kerry S., Inman, Brant A., Muehlbauer, Michael, Nelson, Erik R., Jasper, Jeff, Field, Catherine J., Jones, Lee W., Glass, Oliver K., Bain, James R., Broadwater, Gloria, Goruk, Susan, Hirschey, Matthew D., Mackey, John R.
background: Few studies have investigated the effects of exercise on modulation of host factors in cancer patients. We investigated the efficacy of chronic aerobic training on multiple host-related effector pathways in patients with solid tumours. patients and methods: Paired peripheral blood...
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Effects of Egg White Derived Peptides on Metabolic Syndrome Complications: Hypertension, Inflammation, and Insulin resistance
DownloadSpring 2018
Metabolic syndrome (MetS), a cluster of several abnormalities of hypertension, inflammation, glucose intolerance and dyslipidemia, enhances a personâs risk for cardiovascular disease and type 2 diabetes. The number of people with MetS is increasing largely worldwide. The multi-faceted nature of...
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Effects of Inflammation and Non-Steroidal Anti-Inflammatory Drugs on Renin-Angiotensin System and Cytochrome P450 Metabolites of Arachidonic Acid
DownloadSpring 2016
Patients suffering from inflammatory disorders are at higher risk of cardiovascular (CV) morbidity and mortality compared to general population. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation associated with inflammatory disorders such as rheumatoid...
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Spring 2014
Inflammation is involved in the pathogenesis of some cardiovascular diseases and contributes to the observed increased overall mortality rate. It also influences the action and disposition of drugs including some of the cardiovascular agents that are commonly used by patients with inflammatory...
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Egg-derived tri-peptide IRW exerts antihypertensive effects in spontaneously hypertensive rats
Download2013
Majumder, Kaustav, Kaufman, Susan, Chakrabarti, Subhadeep, Morton, Jude S., Panahi, Sareh, Wu, Jianping, Davidge, Sandra T.
Background There is a growing interest in using functional food components as therapy for cardiovascular diseases such as hypertension. We have previously characterized a tri-peptide IRW (Ile-Arg-Trp) from egg white protein ovotransferrin; this peptide showed anti-inflammatory, anti-oxidant and...
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Fall 2022
Contraction-mediated inhibition of sympathetic vasoconstriction (sympatholysis) is enhanced in female compared with male rats. Acute pharmacological blockade of nitric oxide (NO) production abolished the sex difference in sympatholysis, indicating that NO-mediated sympatholysis is elevated in...
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Spring 2017
Pulses of ecdysone, a steroid hormone, play an integral role during insect development however, how these ecdysone pulses are regulated has been relatively unexplored. I have shown that the presence of nitric oxide (NO) within the larval prothoracic gland (PG), the principal source of larval...
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Exploring Novel Therapies for Motor and Non-Motor Symptoms in a Mouse Model of Multiple Sclerosis
DownloadSpring 2016
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by neurodegeneration, inflammation and demyelination. Symptoms of multiple sclerosis not only include motor deficits, but also secondary symptoms of pain, depression and anxiety. The purpose of...
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Feeding high oleic acid Canola oil or olive oil alters inflammation, insulin resistance and lipid metabolism in a rodent model of diet induced obesity
DownloadFall 2011
To determine the efficacy of feeding monounsaturated fatty acids (MUFA) via a high MUFA Canola oil on T2D risk factors diet induced obese rats were fed either a low fat diet (LF), a high fat low MUFA diet (HF), a high fat high MUFA olive oil diet (OO), or a high fat high MUFA Canola oil diet...