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Skip to Search Results- 1Charrunchon, Sookpichaya
- 1Cuff, Keith O
- 1Halma, Matthew
- 1Healey, Mark A
- 1Ocampo, Benjamin R. S.
- 1Pavlovskii, Konstantin
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Fall 2016
α-Synuclein has been implicated in the progression of Parkinson’s disease, a neurodegenerative disorder that affects millions of people worldwide. This work reports on the structural propensity and druggability of this protein using a combination of Monte Carlo, Molecular Dynamics, and Virtual...
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Force spectroscopy of the frameshift signal from West Nile virus reveals multiple folding pathways and structural heterogeneity
DownloadSpring 2019
Programmed ribosomal frameshifting (PRF) represents an important mechanism for translational genetic recoding, especially in viruses. The components of a PRF stimulator have been well characterized, though accounting for the variation in the frameshift stimulating efficiency has thus far been...
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Spring 2016
In this thesis we study MT from giant and subgiant donors in binary stars. We develop a MT simulation framework based on the MESA set of stellar libraries, which is suitable to study extremely high MT rates and predict the stability of MT. We find that the MT from giant donors is much more stable...
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Numerical Simulations of Anelastic and Boussinesq Rotating Convection with Radial Entropy Gradient Boundary Conditions
DownloadFall 2017
Observations from the gas giants Jupiter or Saturn allow for researchers to construct geophysical fluid dynamical numerical models in an attempt to replicate the observed features. Most models aim at replicating the zonal jets and the eddies observed on these gas giants to understand how they are...
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Spring 2017
In this dissertation we focus on numerical models of rotating anelastic convection, in particular the entropy boundary condition, with application to the giant planets. The first chapter details atmospheric features of giant planets and the numerical formulation of anelastic convection. The...
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Fall 2013
Protein folding involves a stochastic search through the configurational energy landscape towards the native structure. Although most proteins have evolved to fold efficiently into a unique native structure, misfolding (the formation of non-native structures) occurs frequently in vivo causing a...
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Fall 2017
The formation of an abnormal form of proteins in cells can cause aggregation and neurodegenerative pathology, such as Alzheimer’s, Parkinson’s and prion diseases, which affects both humans and animals. Nowadays, the understanding of the mechanism of prion misfolding and propagation, including...