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Skip to Search Results- 1Elezzabi, Muhammad A.
- 1Ellestad, Kristofor K
- 1Havele, Calliopi.
- 1Hu, Qian
- 1Sadelain, Michel W. J.
- 1Smolarchuk, Christa
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Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic Sclerosis
DownloadFall 2023
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
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Contributions of Bim and Nur77 to multiple mechanisms of T cell tolerance following high affinity antigen encounter
DownloadSpring 2015
Prevention of autoimmune disease requires the elimination or inactivation of T cells that are highly reactive to self-peptides. During T cell development in the thymus, self-reactive thymocytes undergo negative selection upon receiving a high affinity T cell receptor (TCR) signal following...
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Mechanisms underlying lymphopenia-driven autoimmunity in the setting of co-inhibitory molecule deficiency
DownloadFall 2016
T lymphocytes (T cells) are powerful directors and effectors of immunity. The system of pseudo-random rearrangements of the T cell receptor (TCR) loci that underlie their ability to recognize a vast universe of molecular patterns is at once useful and dangerous, because many T cells develop TCR...
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Fall 2011
The main function of co-inhibitory molecules is to regulate T cell immune responses by providing negative signals to those cells. Homeostatic activation of T cells occurs in both natural and artificially induced states of lymphopenia. Although lymphopenia leads to homeostatic proliferation of T...
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T Cell Generation in a Lymphopenic Environment Generates Disease when the Thoracic Thymus is Eliminated; Augmentation by IL-7/Anti-IL-7 Complexes
DownloadSpring 2012
Cervical thymus functionally mimics the thoracic thymus in supporting T cell development and exists in a subset of mice and humans. Importantly, it remains unknown whether the cervical thymus generates an overall repertoire of T cells that are self-tolerant similar to the thoracic thymus. Mice...