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Skip to Search Results- 1Ataeian, Maryam
- 1Ayoub, Ahmed T
- 1Bajaj, Megha
- 1Brockley, Graham Hardcastle.
- 1Churchill, Cassandra D.M.
- 1Curtis Pahara, Donna
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Microtubules and Energy Metabolism: Targets for Standard, Combination, and Novel Therapeutic Interventions and Monitoring of Cancer
DownloadSpring 2016
The challenge of understanding and treating cancer has proven to be exceedingly complex. At this juncture, understanding cancer from the perspective of a breakdown of a complex cooperative system using a biophysical analysis may aid in improved treatments and prevention of this disease. In any...
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N6-methyladenosine bimodal peak signature mediates acute and selective stress translation by specialized cytoskeletal ribosomes via a MARK4-FTO-PKR axis
DownloadSpring 2023
Cellular responses to stress are temporally-organized complex pathways designed to prioritize resources and adapt in order to promote repair and survival. In severe stress, the energetically demanding mRNA translation is mostly inhibited, but it is not known whether there is a universal mechanism...
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Fall 2014
Regulation of microtubule dynamics is essential for many cellular processes, including proper assembly and function of the mitotic spindle. One mechanism for temporal and spatial regulation of microtubule dynamics is provided by the kinesin-13 microtubule depolymerizing enzymes, among which MCAK...
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Using 1H-NMR based metabolomics to investigate the pathological consequences of mitochondrial disease and human rabies infection
DownloadSpring 2012
Mitochondrial diseases encompass a wide range of clinical phenotypes. The etiology of these disorders is extremely complex; mitochondria are central to energy metabolism and dysfunction can have a profound effect on global metabolism. The original objective of this thesis was to use 1H-NMR based...