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Spring 2022
Carotid atherosclerosis is responsible for 15-25% of the nearly 8 million first-ever ischemic strokes that occur each year worldwide. This proportion has remained constant over the past three decades, thus suggesting that some patients with carotid atherosclerosis currently receive suboptimal...
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Spring 2014
Lower-extremity peripheral artery disease (PAD) is a manifestation of atherosclerotic disease in the lower limbs. PAD is a risk factor for poor outcomes including myocardial infarction, stroke, and mortality. Despite the potential benefits of early PAD detection, in the majority of PAD cases...
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Effects of High-Intensity Aerobic Interval Training on Cardiovascular Disease Risk and Health-related Quality of Life in Testicular Cancer Survivors: The HIITTS Trial
DownloadFall 2017
Background: Testicular cancer (TC) survivors (TCS) are an understudied, high-risk group susceptible to late-onset treatment-related cardiovascular disease (CVD), psychosocial, and health-related quality of life (HRQoL) deficits in the years following treatment. Importantly, despite having the...
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Exploring the Role of ADAM17 in Vascular Smooth Muscle Cells and Macrophages Within the Atherosclerotic Plaque
DownloadSpring 2024
Atherosclerosis, characterized by arterial fat deposits, is the root cause of many cardiovascular diseases. Plaque deposition results from a series of events initiated by elevated plasma cholesterol, inflammation of the arterial wall, cholesterol uptake, macrophage-derived foam cell formation,...
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Insights into Membrane Type-1 Matrix Metalloproteinase cleavage of the Low-density Lipoprotein Receptor
DownloadSpring 2021
The Low-density lipoprotein receptor (LDLR) mediated cellular uptake of LDL is the main pathway for plasma LDL cholesterol (LDL-C) clearance. However, the LDLR can be proteolytically cleaved to release its soluble ectodomain (sLDLR) into the extracellular milieu and as such reducing its LDL-C...
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Investigating the role of coiled-coil domain containing protein 3 (CCDC3), a novel secreted protein, in endothelial inflammation
DownloadFall 2015
Endothelial inflammation is critical in the initiation and progression of atherosclerosis and other cardiovascular diseases (CVDs). Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine that induces endothelial inflammation via activation of nuclear factor κB (NF-κB) signaling....
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Spring 2024
Background and Objective High-fat Western diets have been linked to the dysregulation of fatty acids (FA) and glucose intake in tissues, resulting in adverse metabolic outcomes such as obesity, insulin resistance, and atherosclerosis. There is a pressing need for new therapeutic approaches to...
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Fall 2017
Phosphatidylethanolamine N-methyltransferase (PEMT) is a hepatic enzyme that converts phosphatidylethanolamine to phosphatidylcholine. Pemt-/- mice are protected from obesity and insulin resistance, a phenotype that is reversed with dietary choline supplementation. Additionally, PEMT deficiency...
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Spring 2023
Atherosclerosis and aortic aneurysms are two major vascular diseases, and extracellular matrix (ECM) plays an important role in both as a non-cellular component of the aortic wall that also regulates vascular cell behavior and function. Atherosclerosis is a major contributor to cardiovascular...
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Spring 2014
Modifiable cardiovascular disease (CVD) risk factors, such as adiposity, are already associated with atherosclerotic progression in childhood. Less is known about whether physical activity (PA) is associated with progression of atherosclerosis in non-clinical samples of children. This...