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- 4Cardiovascular diseases
- 2Health-related quality of life
- 1Adams, Scott C
- 1Alabi, Adekunle
- 1Aldana Hernandez, Paulina
- 1Azad, Abul K
- 1Ban, Matthew R.
- 1Bjerregaard, Peter
- 9Graduate Studies and Research, Faculty of
- 9Graduate Studies and Research, Faculty of/Theses and Dissertations
- 1Agricultural, Food and Nutritional Science, Department of
- 1Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 1Nursing, Faculty of
- 1Nursing, Faculty of/Chronicity
- 3Department of Agricultural, Food, and Nutritional Science
- 1Department of Agricultural, Food and Nutritional Science
- 1Department of Biochemistry
- 1Department of Medicine
- 1Department of Oncology
- 1Department of Public Health Sciences
Common variants APOC3, APOA5, APOE and PON1 are associated with variation in plasma lipoprotein traits in GreenlandersDownload
"Objectives: We undertook studies of the association between common genomic variations in APOC3, APOA5, APOE and PON1 genes and variation in biochemical phenotypes in a sample of Greenlanders. Study Design: Genetic association study of quantitative lipoprotein traits. Methods: In a sample of...
Lower-extremity peripheral artery disease (PAD) is a manifestation of atherosclerotic disease in the lower limbs. PAD is a risk factor for poor outcomes including myocardial infarction, stroke, and mortality. Despite the potential benefits of early PAD detection, in the majority of PAD cases...
Effects of High-Intensity Aerobic Interval Training on Cardiovascular Disease Risk and Health-related Quality of Life in Testicular Cancer Survivors: The HIITTS TrialDownload
Background: Testicular cancer (TC) survivors (TCS) are an understudied, high-risk group susceptible to late-onset treatment-related cardiovascular disease (CVD), psychosocial, and health-related quality of life (HRQoL) deficits in the years following treatment. Importantly, despite having the...
Insights into Membrane Type-1 Matrix Metalloproteinase cleavage of the Low-density Lipoprotein ReceptorDownload
The Low-density lipoprotein receptor (LDLR) mediated cellular uptake of LDL is the main pathway for plasma LDL cholesterol (LDL-C) clearance. However, the LDLR can be proteolytically cleaved to release its soluble ectodomain (sLDLR) into the extracellular milieu and as such reducing its LDL-C...
Investigating the role of coiled-coil domain containing protein 3 (CCDC3), a novel secreted protein, in endothelial inflammationDownload
Endothelial inflammation is critical in the initiation and progression of atherosclerosis and other cardiovascular diseases (CVDs). Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine that induces endothelial inflammation via activation of nuclear factor κB (NF-κB) signaling....
Phosphatidylethanolamine N-methyltransferase (PEMT) is a hepatic enzyme that converts phosphatidylethanolamine to phosphatidylcholine. Pemt-/- mice are protected from obesity and insulin resistance, a phenotype that is reversed with dietary choline supplementation. Additionally, PEMT deficiency...
Modifiable cardiovascular disease (CVD) risk factors, such as adiposity, are already associated with atherosclerotic progression in childhood. Less is known about whether physical activity (PA) is associated with progression of atherosclerosis in non-clinical samples of children. This...
The Role of Intestinal Derived Remnant Lipoproteins in the Progression of Atherosclerosis in Animal Models of Type 1 and Type 2 Diabetes.Download
Introduction: Subjects with insulin resistance (IR) and diabetes are at increased risk of cardiovascular disease (CVD) than those without diabetes, however the mechanistic basis remains elusive. Despite LDL-cholesterol lowering by statin therapy, two-thirds of all CVD events remain, constituting...
Choline, as an essential nutrient, is needed for a variety of biological processes such as phospholipid synthesis, cell-membrane signaling, lipoprotein secretion, acetylcholine biosynthesis, and one-carbon metabolism. In the North American population diet the two most common forms of choline in...