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Skip to Search Results- 1Capitanio, Juliana S.
- 1Dahal, Abhishek
- 1Jeffery, Andrea F
- 1Ourdev, Dimitar
- 1Peake, Kyle
- 1Rajani, Vishaal
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Alteration of astrocyte markers and phosphorylation of tau protein in kainic acid-treated animal model of Temporal Lobe Epilepsy
DownloadFall 2022
Kainic acid, an analogue of the excitatory neurotransmitter glutamate, when administered systemically can trigger seizures and neuronal loss in a manner that mirrors the neuropathology of human mesial temporal lobe epilepsy (mTLE), which affects ~50million people globally. Evidence suggests that...
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Spring 2014
Recent technological advancements in the field of neural recording and decoding have changed the landscape of neural prostheses. However, a lack of biocompatible electrodes for long-term neural recording resulting in loss of electrode functionality is currently a major limiting factor for...
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Spring 2011
Niemann-Pick Type C (NPC) disease is an autosomal recessive disorder that results in accumulation of unesterified cholesterol in late endosomes/lysosomes (LE/Ls), leading to progressive neurodegeneration and premature death. Microglia are resident immune cells of the central nervous system, which...
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Glial Expression of Amyloid Precursor Protein (APP) and its Processing Enzymes in the ANPC Mouse Model
DownloadFall 2021
Alzheimer’s disease (AD) is a complex and progressive neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ) peptides derived from the proteolytic processing of amyloid precursor protein (APP). The regions primarily affected in AD brains are the hippocampus and...
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Intracortical administration of pleiotrophin in ischemic stroke: investigating functional outcomes and glial expression
DownloadSpring 2023
Ischemic stroke is the leading cause of disability and third leading cause of death in Canada, exerting a serious burden on stroke survivors, their families, and healthcare resources. Characterized by brain damage due to loss of blood flow and oxygen supply, ischemic stroke is characterized by...
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Fall 2017
The nucleus is a hallmark of eukaryotic cells. It segregates the genetic material from the cytoplasm. The nucleus is encapsulated by the nuclear envelope which is perforated with nuclear pore complexes (NPCs), macromolecular structures formed by proteins termed nucleoporins (Nups). NPCs and...
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Spring 2016
The hypoxic ventilatory response comprises of an initial increase in ventilation, followed by a secondary depression that can be life threatening in premature infants. During hypoxia, ATP is released in the ventrolateral medulla, where it is suggested to attenuate the secondary hypoxic...
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The role of β-amyloid peptides in kainic acid-induced toxicity and its implications in Mesial Temporal Lobe Epilepsy
DownloadFall 2017
Kainic acid is a non-degradable analogue of the excitatory neurotransmitter glutamate that, when injected systemically into adult rats, can trigger seizures and progressive neuronal loss in a manner that mirrors the neuropathology of human mesial temporal lobe epilepsy (MTLE), most prevalent form...
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Tiered Behaviour Architecture for Virtual Characters using Cyclic Scheduling and Behaviour Capture
DownloadSpring 2015
A story-based video game contains many characters. A few are controlled by the player and the majority are virtual characters, controlled by artificial intelligence. In recent years, video game artificial intelligence has developed slower than other aspects of video games, such as graphics,...
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Spring 2023
Many competitive online video games release new characters on a regular basis. Designing these characters requires significant effort on several aspects including art, story, music, and game balance. Thus automating the design of these aspects offers value in saving human effort. This thesis...