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Skip to Search Results- 9Arachidonic acid
- 5Mouse
- 3Cardiac hypertrophy
- 3Docosahexaenoic acid
- 2Cytochrome P450
- 2Pancreatic beta cells
- 1Aghazadeh Habashi, Ali
- 1Al Lawati, Hanan M
- 1Alsaad,Abdulaziz M
- 1Beaulieu, Michael J.
- 1El-Sherbeni, Ahmed Abd El-Hakeem
- 1Elkhatali, Samya
- 5Faculty of Pharmacy and Pharmaceutical Sciences
- 2Department of Agricultural, Food, and Nutritional Science
- 2Department of Physiology
- 1Centre for Neuroscience
- 1Department of Biological Sciences
- 1Department of Oncology
- 1Anderson, Colin (Department of Surgery) (Department of Medicine and Medical Microbiology & Immunology)
- 1Brocks, Dion (Pharmacy and Pharmaceutical Sciences)
- 1Ding, Jie (Department of Surgery)
- 1Dr. Ayman El-Kadi
- 1El-Kadi, Ayman (Faculty of pharmacy and pharmaceutical sciences)
- 1El-Kadi, Ayman (Pharmacy and Pharmaceutical Sciences)
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Characterization of hypertrophic scar formation in nude and knockout mice deficient in T, B and natural killer cells
DownloadSpring 2012
Introduction: Hypertrophic scar (HSc) is a fibroproliferative disorder lacking a relevant animal model. Our objective is to characterize proliferative scars in human xenografts generated after grafting human skin onto mice deficient in T, B and natural killer cells. Methods: Nude, T-cell receptor...
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Spring 2010
CECR1 (cat eye syndrome chromosome region, candidate 1) is located on chromosome 22q11.2. Duplication of this region results in the human disorder cat eye syndrome (CES), which includes a variety of heart defects. CECR1 is suggested to be dosage sensitive, based on a predicted role in controlling...
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Spring 2012
Human cytomegalovirus (HCMV) is implicated in several vascular diseases through endothelial dysfunction. Most of the research on CMV has focused on either congenital CMV infections or CMV disease in immunocompromised hosts; however, CMV has also been associated with vascular diseases in...
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Development of Polymeric Micelles for Site Specific Delivery of Nonsteroidal Anti-Inflammatory Drugs: Effect on the Cardiovascular Risk in an Experimental Model of Arthritis
DownloadFall 2019
Non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX) enzymes, are among the most widely used medications worldwide with proven efficacy in controlling inflammation and pain associated various disease conditions. The chronic systemic use of most NSAIDs, however, is...
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Evaluating the effects of dietary docosahexaenoic acid along with arachidonic acid during the development of the immune system in early life.
DownloadSpring 2023
The immune system is immature at birth and the dietary fats provided during early life play an important role in the development of the infant’s immune system. The precursor omega-3 (n-3) and n-6 polyunsaturated fatty acids (PUFAs) α-linolenic acid and linoleic acids, respectively, are essential...
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Glucosamine Anti-Inflammatory Dose-Effect Correlation and Its Influence on the Renin-Angiotensin System Components and Arachidonic Acid Metabolites under Inflammatory Condition in the Rat with Adjuvant Arthritis
DownloadSpring 2015
Crystalline glucosamine (GlcN) sulfate salt formulation is approved as a prescription drug with anti-inflammatory effects for the management of osteoarthritis (OA) in the European Union, while it is considered as a nutraceutical in North America. The effectiveness of GlcN for ameliorating the...
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Influence of lipids (arachidonic acid and cholesterol) on calcium signalling in rodent pancreatic beta cells
DownloadFall 2010
Ca2+ is an important mediator of stimulus-secretion coupling in beta cells of the pancreatic islets, which secrete insulin in response to elevation in plasma glucose concentration. I studied the actions of two lipids, arachidonic acid (AA) and cholesterol, on enzymatically-dissociated single...
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Maternal Essential Fatty Acid Status During Pregnancy and Postpartum in the Alberta Pregnancy Outcomes and Nutrition (APrON) Study and Infant Outcomes
DownloadSpring 2017
Docosahexaenoic (DHA) and arachidonic (AA) acids are essential fatty acids found in breast milk and are important for the infant’s brain development and cognitive functions such as those that regulate sleep and crying. The overall goal of this research was to use a large maternal infant cohort,...
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Fall 2012
Malignant gliomas (MG) are the most common and aggressive brain cancers. FABP7 is an intracellular lipid trafficking molecule whose expression correlates with reduced MG patient survival. FABP7 has been shown to increase the migratory behaviour of MG cells. Moreover, the migratory behaviour of...