Search
Skip to Search Results- 1Charrunchon, Sookpichaya
- 1Guthrie, Joshua D
- 1Halma, Matthew
- 1Healey, Mark A
- 1Lecoanet, Alexandre J L
- 1Sand, Rheanna M.
-
Spring 2012
Voltage-gated potassium (Kv) channels regulate the flow of potassium ions across the cell membrane of nerves and muscles. Proper functioning of these and other voltage-gated ion channels is critical for an animal to sense the environment and respond quickly to stimuli. Dysfunctional Kv channels,...
-
Fall 2016
α-Synuclein has been implicated in the progression of Parkinson’s disease, a neurodegenerative disorder that affects millions of people worldwide. This work reports on the structural propensity and druggability of this protein using a combination of Monte Carlo, Molecular Dynamics, and Virtual...
-
Finite Element Model of the Thermal Profile During Submerged Arc Welding with One and Two Electrodes
DownloadFall 2016
The submerged-arc welding (SAW) process is used extensively in the manufacturing of pipes. The heat flow introduced by the welding operation has a significant impact on the properties of both the weld metal and the heat affected zone (HAZ). The work presented in this thesis aims to develop a...
-
Force spectroscopy of the frameshift signal from West Nile virus reveals multiple folding pathways and structural heterogeneity
DownloadSpring 2019
Programmed ribosomal frameshifting (PRF) represents an important mechanism for translational genetic recoding, especially in viruses. The components of a PRF stimulator have been well characterized, though accounting for the variation in the frameshift stimulating efficiency has thus far been...
-
Quantitatively Modelling the Transition from Non-Genetic to Genetic Antimicrobial Resistance
DownloadSpring 2024
Antimicrobial resistance is a growing global health crisis that requires an interdisciplinary approach to better understand and combat. Physics-based modelling has provided valuable insights into the underlying mechanisms of antimicrobial resistance and the quantitative behaviour of resistant...
-
Fall 2013
Protein folding involves a stochastic search through the configurational energy landscape towards the native structure. Although most proteins have evolved to fold efficiently into a unique native structure, misfolding (the formation of non-native structures) occurs frequently in vivo causing a...
-
Fall 2017
The formation of an abnormal form of proteins in cells can cause aggregation and neurodegenerative pathology, such as Alzheimer’s, Parkinson’s and prion diseases, which affects both humans and animals. Nowadays, the understanding of the mechanism of prion misfolding and propagation, including...