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Skip to Search Results- 1Anderson, Sharon
- 1Anderson, Sharon D
- 1Arvanitidis, Anastasia P
- 1Auriat, Angela Michelle
- 1Caliaperumal, Jayalakshmi
- 1Clair, Joanna
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Hypothermia and the Evaluation of Combination Therapies for Neonatal Hypoxic-Ischemic Brain Damage
DownloadFall 2016
Hypoxic-ischemic brain damage (HIBD) is still of major concern in the neonatal period, resulting in chronic neurological sequelae stemming from damage to the term newborn brain. Full-body and focal-head cooling within 6 hours of birth have proven neuroprotective in human newborns and various...
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Influence of therapeutic hypothermia on neuroprotection and post-ischemic plasticity in a rat model of global ischemia
DownloadFall 2011
Blood flow to the brain may be disrupted by either a stroke (such as focal ischemia or hemorrhage) or cardiac arrest, where the whole brain becomes ischemic. Both forms of injury result in irreversible neuronal loss leading to neurological impairments and a decrease in the quality of life....
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Intracortical administration of pleiotrophin in ischemic stroke: investigating functional outcomes and glial expression
DownloadSpring 2023
Ischemic stroke is the leading cause of disability and third leading cause of death in Canada, exerting a serious burden on stroke survivors, their families, and healthcare resources. Characterized by brain damage due to loss of blood flow and oxygen supply, ischemic stroke is characterized by...
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Fall 2020
Intracerebral hemorrhage (ICH), when a blood vessel ruptures within the brain, affects approximately 15% of stroke victims in Canada. There are no proven neuroprotective treatments ICH but two therapies, therapeutic hypothermia (TH) and iron-chelators, have gained preclinical and clinical...
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Spring 2014
Bleeding within the brain parenchyma causes a severe form of stroke named intracerebral hemorrhagic stroke (ICH). An understanding of how brain injury occurs after an ICH may suggest alternative therapies. For this reason, the current dissertation focuses on two important questions of how the...
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Fall 2016
This thesis discusses the pathophysiological mechanisms underlying neuromotor impairments in people with spastic cerebral palsy (CP). Ninety percent of people with CP have spastic CP and 60% have bilateral motor impairments. The first two chapters introduce CP and review the mechanisms known to...
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Fall 2012
Reading impairment, known as alexia, frequently co-occurs with damage to the language areas of the brain in aphasia. Text-based reading treatments have been shown to improve reading fluency, but the mechanisms behind such improvement remain unclear. This study investigates the efficacy of...
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Spring 2018
Background: Stroke is a leading cause of adult disability globally. In Canada, about 405,000 individuals are living with the effects of stroke and this number is projected to rise by over 60% in the next two decades. People with stroke are often physically inactive and sedentary which may...
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Neuronal Mechanisms of Hyperexcitability in Individuals with Spasticity after Spinal Cord Injury and Individuals with Bruxism
DownloadFall 2013
Motoneuron hyperexcitability is a characteristic of several different motor disorders. We examined neuronal mechanisms of hyperexcitability in two of these disorders: spasticity after spinal cord injury (SCI) and bruxism. Involuntary muscle spasms after SCI occur as a result of uncontrolled...
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Pairing Reading Treatment with Transcranial Direct Current Stimulation for Adults with Aphasia
DownloadSpring 2020
Background. Damage to language areas of the brain often leads to a language disorder called aphasia, which impairs speech, writing, and understanding. Sixty-eight per cent of people with aphasia (PWA) also present with alexia, a reading impairment. There is an urgent need for efficacious...